bendroflumethiazide


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bendroflumethiazide

 [ben″dro-floo″mĕ-thi´ah-zīd]
a thiazide diuretic and antihypertensive agent; it enhances the excretion of sodium and chloride.

bendroflumethiazide

/ben·dro·flu·me·thi·a·zide/ (ben″dro-floo″mĕ-thi´ah-zīd) a thiazide diuretic used to treat hypertension and edema.

bendroflumethiazide

[ben′drōflo̅o̅′məthī′əzīd]
a diuretic and antihypertensive.
indications It is prescribed in the treatment of hypertension and edema.
contraindications Anuria or known hypersensitivity to this drug, to other thiazide medication, or to sulfonamide derivatives prohibits its use.
adverse effects Among the more serious are hypokalemia, hyperglycemia, hyperuricemia, and hypersensitivity reactions.

diuretics

powerful drugs, often termed 'water tablets', that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide
Table 1: Principal drug interactions of local anaesthetic agents and other medications
Local anaesthetic agent Proprietary name Principal drug interactionsEffect of interaction
Lidocaine
Xylocaine
Antiarrhythmic agents
Antibacterial agents
Antipsychotics
Antivirals
Beta-blockers
Diuretics
Dolasetron
Ulcer-healing drugs
Increased myocardial depression
Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin
Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle
Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir
Increased myocardial depression
Increased risk of lidocaine toxicity when given with propranolol
The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)
Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron
Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
Bupivacaine
Marcain
Levo-bupivacaine
Chirocaine
Beta-blockersIncreased risk of bupivacaine toxicity when given with propranolol
Increased risk of myocardial depression if given with other antiarrhythmic agents
Prilocaine
Citanest
Antiarrhythmic agents
Antibacterial agents
Increased risk of myocardial depression if given with antiarrhythmic agents
Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
Ropivacaine
Naropin
AntidepressantsMetabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity
Mepivacaine
Scandonest
Drug not listed in the British National Formulary

bendroflumethiazide, bendrofluazide

a thiazide diuretic and antihypertensive; it enhances the excretion of sodium and chloride.
References in periodicals archive ?
Bendroflumethiazide also works well in older patients, but some are unwilling to put up with the increased urinary frequency that is a side-effect of water tablets.
BARCELONA -- An antihypertensive treatment regimen of amlodipine plus perindopril led to 34% fewer cases of new-onset diabetes, compared with a regimen of atenolol plus bendroflumethiazide, in a controlled study with more than 14,000 hypertensive patients.
The medication includes Citalopran Hydro Bromide, which are anti-depressants, and Bendroflumethiazide, which are blood pressure tablets.
Like all participants in ASCOT, these hypertensive patients were randomized to treatment with either of two regimens: amlodipine, followed by perindopril when a second drug was needed to reach the goal brachialartery pressure, or atenolol, with the diuretic bendroflumethiazide and potassium added when a second drug was needed.
The second arm used the [beta]-blocker atenolol as the primary drug, with the diuretic bendroflumethiazide and potassium added when a second drug was needed.
ASCOT-BPLA studied 19,257 high-risk hypertensive patients on amlodipine (Norvasc), adding perindopril, or atenolol (Tenormin), adding bendroflumethiazide.
Like all participants in ASCOT, these hypertensive patients were randomized to treatment with either of two regimens: amlodipine, followed by perindopril when a second drug was needed to reach the goal brachial-artery pressure, or atenolol, with the diuretic bendroflumethiazide and potassium added when a second drug was needed.
Sever reported on 19,257 hypertensive patients free of coronary heart disease who participated in the Anglo-Scandinavian Cardiac Outcomes Trial Blood Pressure-Lowering Arm (ASCOT-BPLA) who were randomized to amlodipine/perindopril or atenolol / bendroflumethiazide.
Other possible explanations include a suspected adverse interaction between atenolol/ bendroflumethiazide and statin therapy, and more effective inhibition of the renin-angiotensin system by amlodipine/perindopril.
Effectiveness of nadolol versus bendroflumethiazide alone and in combination in the treatment of hypertension.
He reported on 160 hypertensive British ethnic Asian Indians in a double-blind, 36 week clinical trial at 17 primary care centers in the United Kingdom in which they were randomized to antihypertensive therapy with the alpha-1 receptor blocker doxazosin or bendroflumethiazide.
Fasting insulin was significantly lower at 21 and 34 weeks in the doxazosin group than in bendroflumethiazide group.