bendroflumethiazide

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bendroflumethiazide

[ben″dro-floo″mĕ-thi´ah-zīd]

a thiazide diuretic and antihypertensive agent; it enhances the excretion of sodium and chloride.

bendroflumethiazide

/ben·dro·flu·me·thi·a·zide/ (ben″dro-floo″mĕ-thi´ah-zīd) a thiazide diuretic used to treat hypertension and edema.

bendroflumethiazide

[ben′drōflo̅o̅′məthī′əzīd]

a diuretic and antihypertensive.

indications It is prescribed in the treatment of hypertension and edema.

contraindications Anuria or known hypersensitivity to this drug, to other thiazide medication, or to sulfonamide derivatives prohibits its use.

adverse effects Among the more serious are hypokalemia, hyperglycemia, hyperuricemia, and hypersensitivity reactions.

diuretics

powerful drugs, often termed 'water tablets', that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide

**Table 1:** Principal drug interactions of local anaesthetic agents and other medications
Local anaesthetic agent Proprietary name	Principal drug interactions	Effect of interaction
Lidocaine Xylocaine	Antiarrhythmic agents Antibacterial agents Antipsychotics Antivirals Beta-blockers Diuretics Dolasetron Ulcer-healing drugs	Increased myocardial depression Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir Increased myocardial depression Increased risk of lidocaine toxicity when given with propranolol The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia) Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
Bupivacaine Marcain Levo-bupivacaine Chirocaine	Beta-blockers	Increased risk of bupivacaine toxicity when given with propranolol Increased risk of myocardial depression if given with other antiarrhythmic agents
Prilocaine Citanest	Antiarrhythmic agents Antibacterial agents	Increased risk of myocardial depression if given with antiarrhythmic agents Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
Ropivacaine Naropin	Antidepressants	Metabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity
Mepivacaine Scandonest	Drug not listed in the British National Formulary

bendroflumethiazide, bendrofluazide

a thiazide diuretic and antihypertensive; it enhances the excretion of sodium and chloride.

References in periodicals archive ?

Bendroflumethiazide also works well in older patients, but some are unwilling to put up with the increased urinary frequency that is a side-effect of water tablets.

Steps to a safer blood pressure

BARCELONA -- An antihypertensive treatment regimen of amlodipine plus perindopril led to 34% fewer cases of new-onset diabetes, compared with a regimen of atenolol plus bendroflumethiazide, in a controlled study with more than 14,000 hypertensive patients.

Amlodipine, perindopril combo cuts new-onset diabetes

The medication includes Citalopran Hydro Bromide, which are anti-depressants, and Bendroflumethiazide, which are blood pressure tablets.

Alert over lost drugs

Like all participants in ASCOT, these hypertensive patients were randomized to treatment with either of two regimens: amlodipine, followed by perindopril when a second drug was needed to reach the goal brachialartery pressure, or atenolol, with the diuretic bendroflumethiazide and potassium added when a second drug was needed.

Central pressure changes may drive amlodipine's advantage

The second arm used the [beta]-blocker atenolol as the primary drug, with the diuretic bendroflumethiazide and potassium added when a second drug was needed.

Data point to amlodipine, atorvastatin synergy: evidence obtained from ASCOT may lead to more aggressive use of statins in hypertensive patients

ASCOT-BPLA studied 19,257 high-risk hypertensive patients on amlodipine (Norvasc), adding perindopril, or atenolol (Tenormin), adding bendroflumethiazide.

What we really need to do to reduce cardiovascular events in hypertensive patients: treatment to goal is key--not which antihypertensive you start with, according to this review

Like all participants in ASCOT, these hypertensive patients were randomized to treatment with either of two regimens: amlodipine, followed by perindopril when a second drug was needed to reach the goal brachial-artery pressure, or atenolol, with the diuretic bendroflumethiazide and potassium added when a second drug was needed.

Central pressure changes may give advantage to amlodipine

Sever reported on 19,257 hypertensive patients free of coronary heart disease who participated in the Anglo-Scandinavian Cardiac Outcomes Trial Blood Pressure-Lowering Arm (ASCOT-BPLA) who were randomized to amlodipine/perindopril or atenolol / bendroflumethiazide.

Other possible explanations include a suspected adverse interaction between atenolol/ bendroflumethiazide and statin therapy, and more effective inhibition of the renin-angiotensin system by amlodipine/perindopril.

ASCOT findings put new spin on HT combination therapy

Effectiveness of nadolol versus bendroflumethiazide alone and in combination in the treatment of hypertension.

Antihypertensive drug therapy and coronary heart disease risk

He reported on 160 hypertensive British ethnic Asian Indians in a double-blind, 36 week clinical trial at 17 primary care centers in the United Kingdom in which they were randomized to antihypertensive therapy with the alpha-1 receptor blocker doxazosin or bendroflumethiazide.

Help for metabolic syndrome in Asian Indians

Fasting insulin was significantly lower at 21 and 34 weeks in the doxazosin group than in bendroflumethiazide group.