IgD multiple myeloma is characterized by a small or absent M-protein band in electrophoresis, a Lambda (A) light chain bias, and Bence-Jones proteinuria, which occurred in at least 90% of patients (7).
Furthermore, Lolin et al (1994) suggested that immunofix with IgD and IgE antisera should routinely be performed for all patients with a suspected Bence-Jones proteinuria myeloma, irrespective of whether a suspicious band was detected on serum protein electrophoresis or after immunofixation with light chains (9).
3,11,12,14] Tubular dysfunction has been reported in patients with myeloma and Bence-Jones proteinuria.
Bence-Jones proteinuria and renal failure in multiple myeloma.
We retrieved laboratory data on all patients with Bence-Jones proteinuria who had more than four 24-hour urine collections analyzed at Beth Israel Deaconess Medical Center, Boston, Massachusetts, from 2003 through 2008.
The vast majority of these patients excrete these monoclonal light chains in the urine; this has traditionally been termed Bence-Jones proteinuria.
Identification and quantification of Bence-Jones proteinuria
by automated nephelometric screening.