Bence Jones reaction


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Bence Jones re·ac·tion

(bents jōnz),
the classic means of identifying Bence Jones protein, which precipitates when urine (from patients with this type of proteinuria) is gradually warmed to 45-70°C and redissolves when the urine is heated to near boiling; as the specimen cools, the Bence Jones protein precipitates in the indicated range of temperature and redissolves as the temperature of the specimen becomes less than 30-35°C.
[Henry Bence Jones]

Bence Jones reaction

The classic method for identifying the 22–24-kD monoclonal Bence Jones protein (BJP), which is based on precipitation of BJP from urine at 45–70º C (it goes into solution at temperatures above or below this range). While the Bence Jones reaction confirms the presence of  multiple myeloma, Waldenström’s macroglobulinemia, CLL and amyloidosis, it is inelegant; serum-free light-chain assays have greater diagnostic utility than urine tests.

Bence Jones re·ac·tion

(bens jōnz rē-ak'shŭn)
The classic means of identifying Bence Jones protein, which precipitates when urine containing it is gradually warmed to 45-70°C, and redissolves as the urine is heated to near boiling.
[Henry Bence Jones]

Bence Jones,

Henry, English physician, 1814-1873.
Bence Jones albumin
Bence Jones cylinders - slightly irregular, relatively smooth, rod-shaped or cylindroid bodies of fairly tenacious, viscid proteinaceous material in the fluid of the seminal vesicles.
Bence Jones myeloma - multiple myeloma in which the malignant plasma cells excrete only light chains of one type (either kappa or lambda). Synonym(s): L-chain disease; L-chain myeloma
Bence Jones proteins - proteins with unusual thermosolubility found in the urine of patients with multiple myeloma, consisting of monoclonal immunoglobulin light chains.
Bence Jones reaction - the classic means of identifying Bence Jones protein.
Bence Jones test