Benadryl


Also found in: Dictionary, Thesaurus, Wikipedia.

Benadryl

 [ben´ah-dril]
trademark for preparations of diphenhydramine hydrochloride, an antihistamine.

diphenhydramine hydrochloride

Aler-Cap, Aler-Dryl, Allerdryl (CA), AllerMax, Altaryl, Anti-Hist, Banophen, Benadryl, Benadryl Allergy, Benadryl Child Chesty Cough (UK), Benadryl Children's Allergy Fastmelt, Benadryl Dye-Free Allergy, Benadryl Itch Relief, Compoz Nighttime Sleep Aid, Dermamycin, Diphen, Diphenhist, Dytan, Genahist, Histapryn, Histergan (UK), Hydramine, Mandalyn Paedetriac (UK), Nightcalm, Nytol, PMS-Diphenhydramine (CA), Siladryl, Simply Sleep, Sleepeaze (UK), Sleepettes D, Sleepinal, Sominex, Theraflu Thin Strips Multisymptom, Triaminic Thin Strips Children's Cough and Runny Nose, Twilite, Unisom Maximum Strength SleepGels

Pharmacologic class: Ethanolamine derivative, nonselective histamine1-receptor antagonist

Therapeutic class: Antihistamine, antitussive, antiemetic, antivertigo agent, antidyskinetic

Pregnancy risk category B

Action

Interferes with histamine effects at histamine1-receptor sites; prevents but doesn't reverse histamine-mediated response. Also possesses CNS depressant and anticholinergic properties.

Availability

Capsules: 25 mg, 50 mg

Elixir: 12.5 mg/5 ml

Injection: 10 mg/ml, 50 mg/ml

Strips (orally disintegrating): 12.5 mg, 25 mg

Syrup: 12.5 mg/5 ml

Tablets: 25 mg, 50 mg

Tablets (chewable): 12.5 mg, 25 mg

Tablets (orally disintegrating): 12.5 mg

Indications and dosages

Allergy symptoms caused by histamine release (including anaphylaxis, seasonal and perennial allergic rhinitis, and allergic dermatoses); nausea; vertigo

Adults and children over age 12: 25 to 50 mg P.O. q 4 to 6 hours, or 10 to 50 mg I.V. or I.M. q 2 to 3 hours p.r.n. (Some patients may need up to 100 mg.) Don't exceed 400 mg/day.

Children ages 6 to 12: 12.5 to 25 mg P.O. q 4 to 6 hours, or 1.25 mg/kg (37.5 mg/m2) I.M. or I.V. q.i.d. Don't exceed 150 mg/day.

Children ages 2 to 5: 6.25 mg P.O. q 4 to 6 hours. Don't exceed 37.5 mg/day.

Cough

Adults: 25 mg P.O. q 4 hours p.r.n. Don't exceed 150 mg/day.

Children ages 6 to 12: 12.5 mg P.O. q 4 hours. Don't exceed 75 mg/day.

Children ages 2 to 5: 6.25 mg P.O. q 4 hours. Don't exceed 37.5 mg/24 hours.

Dyskinesia; Parkinson's disease

Adults: Initially, 25 mg P.O. t.i.d.; may be increased to a maximum of 50 mg q.i.d.

Mild nighttime sedation

Adults: 50 mg P.O. 20 to 30 minutes before bedtime

Dosage adjustment

• Elderly patients

Off-label uses

• Drug-induced extrapyramidal reactions

Contraindications

• Hypersensitivity to drug
• Alcohol intolerance
• Acute asthma attacks
• MAO inhibitor use within past 14 days
• Breastfeeding
• Neonates, premature infants

Precautions

Use cautiously in:
• severe hepatic disease, angle-closure glaucoma, seizure disorders, prostatic hypertrophy, cardiovascular disease, hyperthyroidism
• elderly patients
• pregnant patients (safety not established)
• children younger than age 2 (safety not established).

Administration

• For motion sickness, administer 30 minutes before activity.
• For I.V. use, check compatibility before mixing with other drugs.
• Inject I.M. dose deep into large muscle mass; rotate sites.
• Discontinue drug 4 days before allergy skin testing to avoid misleading results.

Don't give within 14 days of MAO inhibitors.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (especially in children)

CV: hypotension, palpitations, tachycardia

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency or retention

Skin: photosensitivity

Other: decreased appetite, pain at I.M. injection site

Interactions

Drug-drug.Antihistamines, opioids, sedative-hypnotics: additive CNS depression

Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Drug-diagnostic tests.Skin allergy tests: false-negative results

Hemoglobin, platelets: decreased values

Drug-herbs.Angel's trumpet, jimson weed, scopolia: increased anticholinergic effects

Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• Monitor cardiovascular status, especially in patients with cardiovascular disease.
• Supervise patient during ambulation. Use side rails as necessary.

Patient teaching

• Advise patient to avoid alcohol and other depressants such as sedatives while taking drug.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

Benadryl

(bĕn′ə-drĭl)
A trademark for the drug diphenhydramine hydrochloride.

Benadryl

a trademark for a first-generation antihistamine (diphenhydramine hydrochloride).

Benadryl

A proprietary antihistamine developed in the mid-1940s which, like other older sedating agents, has been associated with fatal RTAs/MVAs.
 
Adverse effects Drowsiness, heartburn, dizziness.

Benadryl®

Diphenhydramine Allergy medicine An antihistamine which, like other older sedating agents, has been associated with fatal MVAs. See Antihistamine.

Benadryl

A brand name for DIPHENHYDRAMINE.

Benadryl,

n.pr brand name for diphenhydramine hydrochloride, an antihistamine with anticholinergic (drying) and sedative side effects.
References in periodicals archive ?
Your vet may give your dog Benadryl (diphenhydramine HCI) and/or dexamethasone, which is a strong anti-inflammatory drug.
Claimant took some Benadryl to counter the allergic reaction and reported to work.
Over-the-counter medications like Benadryl usually clear up most cases, but again, discuss this course of action with a vet beforehand.
However, the court reversed the trial court's ruling to exclude evidence of the allegedly improper rate at which the Benadryl W88 administered, and remanded the case back to the trial court with instructions to issue a revised order in limine consistent with the opinion of the court.
You can even download the BENADRYL Allergy App straight to your iPad or iPhone, which gives the daily pollen count as well as tips and advice on how to identify and treat your hay fever symptoms.
On Wednesday, February 24, 2010, I returned to the allergy clinic because I had had an adverse reaction to the intramuscular Benadryl they had given me.
Previously, in nearly a decade with Warner Lambert and Reckitt-Benckiser, he led multi-functional teams to deliver record increases for consumer product sales, including years of dynamic growth with the Lysol, Easy-Off, Glass Plus, Mop & Glo, Neosporin and Benadryl brands.
I carry Almond Joys, peanut butter crackers, and Benadryl at all times.
WASHINGTON, May 2 -- The Food and Drug Administration on Saturday urged consumers to stop using liquid Tylenol, Motrin, Benadryl and Zyrtec medicines for children and infants after a broad recall announced by the manufacturer, although it said the chance of serious problems was remote.
The voluntary recall affects certain lots of Benadryl, Tylenol, Motrin IB, Rolaids, Simply Sleep, and St.
The voluntary recall affects certain lots of Children's Motrin, Children's Tylenol, Benadryl, Extra Strength Tylenol, Motrin IB, Regular Strength Tylenol, Rolaids, Simply Sleep, St.
The toxicology report released on September 29, shows the DJ had cocaine, OxyContin, Benadryl and another drug used to cut cocaine in his system, reports The China Daily.