Beckwith's syndrome

Beckwith's syndrome

Etymology: John B. Beckwith, American pathologist, b. 1933
a hereditary disorder of unknown cause associated with neonatal hypoglycemia and hyperinsulinism. Clinical manifestations include gigantism, macroglossia, omphalocele or umbilical hernia, visceromegaly, hyperplasia of the kidney and pancreas, and extreme enlargement of the cells of the adrenal cortex. Treatment consists of adequate glucose, diazoxide, and glucocorticoid therapy. Subtotal pancreatectomy is often necessary in cases of beta cell hyperplasia, nesidioblastosis, or beta cell tumor of the pancreas.
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Other young people on the short list for awards include Chrissy Growney, 17, from Murdishaw, who, despite suffering from the growth disorder Beckwith's Syndrome and having had a number of major operations on her legs, is succeeding academically and working as a volunteer in a nursery school.