BAX

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BAX

BAX
A gene located on chromosome 19q13.3-q13.4, which encodes Bax, which belongs to the BCL2 family of proteins with which it forms a heterodimer, together acting as anti- or pro-apoptosis regulators, depending on whether Bax or Bcl-2 is greater. BAX expression is regulated by p53, the tumour suppressor, and is involved in p53-mediated apoptosis.

Bax
A 21-kD protein encoded by BAX, located on chromosome 19q13.3-q13.4, which has significant homology with Bcl-2, the apoptosis repressor, with which it forms a heterodimer. Overexpression of Bax compared to Bcl-2 signifies apoptosis.
References in periodicals archive ?
The truncated form of BID acts to inhibit the Bcl-2-Bcl-xl pathway and to promote activation of Bcl-2-associated X protein and Bcl-2 homologous antagonist killer, thereby inducings cytochrome C release, leading to formation of the apoptosome (16).