The BCL-2 protein
family: opposing activities that mediate cell death.
Cells are pressured toward apoptosis by expression of pro-apoptotic BCL-2 proteins
In addition, Bcl-2 proteins
can activate any of a large family of caspase enzymes, which break down proteins and can degrade and modify various cellular components.
Expression of bcl-2 protein
and transcription of the Epstein-Barr virus bcl-2 homologue BHRF-1 in Hodgkin's disease: implications for different pathogenic mechanisms.
The bcl-2 protein
is a proto-oncogene that promotes oncogenesis by blocking programmed cell death (apoptosis).
Clones with high expression of Bcl-2 protein
or mutant Bcl-2, termed PT67-Bcl-2 and PT67-Bcl2Y21S, were maintained for further analysis.
Pancreatic and kidney tumors also produce the Bcl-2 protein
, he says, making them possible targets for this drug.
The BCL-2 protein
has been reported to be important in many cancers and is the target of Genta's anticancer drug, G3139.
Several studies have shown overexpression of bcl-2 protein
in a variety of solid tumors, including prostatic carcinoma (2), colorectal cancer (3), squamous cell carcinoma (SCC)  of the lung (4), breast cancer (5, 6), and nasopharyngeal malignancies (7).
expression in tumor sections was examined to analyze the mechanism by which guggulsterone inhibits tumor growth.
HL-60bcl-2 cells, which are derived from a stable transfectant clone of the human bcl-2 gene into the HL-60 leukemia cell line, show 5-fold greater expression of the Bcl-2 protein
compared with HL-60neo cells, a control clone transfected with vector alone.
6) More than 85% of FLs in adults demonstrate a characteristic translocation, t(14;18)(q32;q21), involving the bcl-2 gene,16 whereas most pediatric FLs are negative for bcl-2 protein
and lack bcl-2/immunoglobulin heavy chain (IgH) translocations.