bcl-2

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BCL-2

An oncogene that inhibits apoptosis.

Bcl-2

A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t(14;18) translocation results in a hybrid bcl-2/immunoglobulin heavy chain transcript consisting of the 5’ half of the bcl-2 mRNA fused to a truncated immunoglobulin heavy chain mRNA.

Normal expression
It is normally expressed by small B lymphocytes of the mantle and marginal zones and by many T cells.

Abnormal expression
Bcl-2 is over expressed in follicular lymphomas with the translocation t(14;18)(q32;q21), detected in 70 to 95% of follicular lymphomas and 20% of diffuse large B cell lymphomas. Expression is greater in grade I than in grade III follicular lymphomas.

BCL-2

An oncogene that inhibits apoptosis.

bcl-2

Proto-ONCOGENEs. This gene is over-expressed in various tumours, especially non-Hodgkin lymphoma, resulting in resistance to APOPTOSIS (programmed cell death) with encouragement of tumour growth. Antisense nucleotide sequences (oligonucleotides) targeted at BCL-2 messenger RNA reduces the expression of BCL-2 and increases apoptosis in these tumours with clinical improvement.
References in periodicals archive ?
Involvement of the bcl-2 gene in human follicular lymphoma, Science, 228: 1440-3.
dagger]) bcl-2 gene rearrangement and IgH were done in 3 of 4 cases.
Klem, vice president and chief technical officer of Genta, "will provide patent protection for not only our lead anticancer drug G3139 used alone or in combination with chemotherapy agents, but also for any antisense targeting the bcl-2 gene.
Loh's group created mice that carried a defective bcl-2 gene in their immune system cells.
Regulation of Bcl-2 gene expression" (EP Publication No.
Members of the bcl-2 gene family fall into two categories including pro-apoptotic and anti-apoptotic members (Cory and Adams, 1998) reported that members of the bcl-2 gene family play key roles in regulating apoptosis, and at least 15 mammalian bcl-2 gene family members have been identified.
Recent analysis of the Bcl-2 gene family has revealed a complex regulatory network to modulate cell apoptosis.
The bcl-2 gene was originally identified through studies of the t(14:18) chromosomal translocation associated with human follicular B-cell lymphoma (1-3).
Idun Pharmaceuticals and Selective Genetics today announced the signing of a license agreement for the use of Idun's Bcl-2 gene.
In this study, we compare OPF, F&P, and MWH, focusing on the detection of cytoplasmic (bcl-2 and gp-170) and nuclear antigens (p53 and rb/p105), all of which are proteins of interest in diagnostic and research areas: the bcl-2 gene product plays a key role in the inhibition of the programmed cell death or apoptosis; the glycoprotein gp-170, encoded by the MDR-1 gene, is the marker of classical multidrug resistance, for which the importance of quality-control procedures and standardization of detection methods have been emphasized recently (8).
Institute for Allergy and Immunology reports that death-prone cells containing extra c-myc genes survive much longer following insertion of an activated bcl-2 gene, which produces a protein with unknown function.
The application of GeneICE[TM] technology in both studies targeted the BCL-2 gene, which is often over-expressed in certain types of cancer and may lead to the development of chemotherapeutic cell-death resistance.