Involvement of the bcl-2 gene
in human follicular lymphoma, Science, 228: 1440-3.
dagger]) bcl-2 gene
rearrangement and IgH were done in 3 of 4 cases.
Klem, vice president and chief technical officer of Genta, "will provide patent protection for not only our lead anticancer drug G3139 used alone or in combination with chemotherapy agents, but also for any antisense targeting the bcl-2 gene
Loh's group created mice that carried a defective bcl-2 gene
in their immune system cells.
Regulation of Bcl-2 gene
expression" (EP Publication No.
Members of the bcl-2 gene
family fall into two categories including pro-apoptotic and anti-apoptotic members (Cory and Adams, 1998) reported that members of the bcl-2 gene
family play key roles in regulating apoptosis, and at least 15 mammalian bcl-2 gene
family members have been identified.
Recent analysis of the Bcl-2 gene
family has revealed a complex regulatory network to modulate cell apoptosis.
The bcl-2 gene
was originally identified through studies of the t(14:18) chromosomal translocation associated with human follicular B-cell lymphoma (1-3).
Idun Pharmaceuticals and Selective Genetics today announced the signing of a license agreement for the use of Idun's Bcl-2 gene
In this study, we compare OPF, F&P, and MWH, focusing on the detection of cytoplasmic (bcl-2 and gp-170) and nuclear antigens (p53 and rb/p105), all of which are proteins of interest in diagnostic and research areas: the bcl-2 gene
product plays a key role in the inhibition of the programmed cell death or apoptosis; the glycoprotein gp-170, encoded by the MDR-1 gene, is the marker of classical multidrug resistance, for which the importance of quality-control procedures and standardization of detection methods have been emphasized recently (8).
Institute for Allergy and Immunology reports that death-prone cells containing extra c-myc genes survive much longer following insertion of an activated bcl-2 gene
, which produces a protein with unknown function.
The application of GeneICE[TM] technology in both studies targeted the BCL-2 gene
, which is often over-expressed in certain types of cancer and may lead to the development of chemotherapeutic cell-death resistance.