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BCL2
(redirected from Bcl-2)

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.01 sec.
BCL2 (bs-l-t)
n.
A gene associated with non-Hodgkin's lymphoma that normally helps regulate the life span of a white blood cell but when mutated prevents such cells from dying, allowing possible further mutations and the development of cancer.


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Mcl-1 is part of the Bcl-2 protein family, and is regulated by B-RAF proteins, which are mutated in approximately 60 percent of all human melanomas.
The pro-apoptotic gene Bax showed lower transcript and protein levels, whereas the anti-apoptotic gene Bcl-2 showed higher levels in CTPE cells.
Bcl-2 antigen staining was visualized by NovaRED substrate, and other reactions were visualized by DAB substrate (both from Vector).
 
 
 
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