basophil

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Related to Basophils: Monocytes, Lymphocytes, Eosinophils, Neutrophils

basophil

 [ba´so-fil]
1. any structure, cell, or histologic element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size; about 1 per cent bring anticoagulants to inflamed tissues. Called also basophilic leukocyte.
3. one of the hormone-producing basophilic cells of the adenohypophysis; types include gonadotrophs and thyrotrophs. Called also beta cell.

ba·so·phil

, basophile (bā'sō-fil, -fīl),
1. A cell with granules that stain specifically with basic dyes.
2. Synonym(s): basophilic
3. A phagocytic leukocyte of the blood characterized by numerous basophilic granules containing heparin, histamine, and leukotrines; except for its segmented nucleus, it is morphologically and physiologically similar to the mast cell although they originate from different stem cells in the bone marrow.
[baso- + G. philēo, to love]

basophil

/ba·so·phil/ (ba´so-fil)
1. any structure, cell, or histologic element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, relatively pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size.
3. one of the hormone-producing basophilic cells of the adenohypophysis; types include gonadotrophs and thyrotrophs. basophil´ic

basophil

(bā′sə-fĭl, -zə-) also

basophile

(-fīl′, -fĭl)
n.
A cell, especially a white blood cell, having granules that stain readily with basic dyes.

basophil

[bā′səfil]
Etymology: Gk, basis + philein, to love
a granulocytic white blood cell characterized by cytoplasmic granules that stain blue when exposed to a basic dye. Basophils represent 1% or less of the total white blood cell count. The relative number of basophils increases in myeloproliferative diseases and decreases in severe allergic reactions. An increase in number is seen during the healing phase of inflammation. Basophils produce histamine during inflammatory reactions. Also called basophilic erythrocyte.Compare eosinophil,neutrophil.See also agranulocyte,differential white blood cell count,granulocyte,leukocyte. basophilic, adj.
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Basophil

basophil

A type of granular leukocyte with large, distinctly basophilic/“blue” secondary granules containing heparin, histamine, platelet-activating factor (PAF) and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high-affinity Fc receptors on the cell surface.

basophil

Basophilic granulocyte Hematology A type of granular WBC with large distinctly basophilic/“blue” 2º granules containing heparin, histamine, PAF and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high affinity Fc receptors on the cell surface

ba·so·phil

, basophile (bā'sō-fil, -fīl)
1. A cell with granules that stain specifically with basic dyes.
2. Synonym(s): basophilic.
3. A phagocytic leukocyte of the blood characterized by basophilic granules containing heparin and histamine; except for its segmented nucleus, it is morphologically and physiologically similar to the mast cell, although the two cell types originate from different stem cells in the bone marrow.
[baso- + G. philēo, to love]

basophil

Having an affinity for alkali. The term is used conveniently to refer to the group of blood white cells (leukocytes) whose internal granules take up an alkaline stain. The granules in basophils are mainly histamine and it is the release of this powerful chemical that causes most of the trouble in allergy. Basophils closely resemble tissue MAST CELLS.

Basophil

White blood cell that increases in response to parasitic infections and allergic reactions.

basophil

a granular white blood cell (leukocyte) that takes up non-acidic stains

basophil,

n white blood cell with cytoplasmic granules and histamines used to direct other WBCs to inflamed areas.
Enlarge picture
Basophils.

ba·so·phil

, basophile (bā'sō-fil, -fīl)
A phagocytic leukocyte of the blood characterized by numerous basophilic granules containing heparin, histamine, and leukotrines.
[baso- + G. philēo, to love]

basophil (bā´səfil),

basophil

1. any structure, cell or histological element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, relatively pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size.
3. a beta cell of the adenohypophysis.

basophil cell
a beta cell of the adenohypophysis which produces luteinizing and follicle stimulating hormones.
basophil degranulation test
an in vitro cellular test for immediate hypersensitivity; it detects degranulation of basophils, by their loss of affinity for staining, when blood from a hypersensitive dog is incubated with allergen extracts.
References in periodicals archive ?
Vancomycin-induced release of histamine from rat peritoneal mast cells and a rat basophil cell line (RBL-1).
If female patients with CFS and MCS and HT-related autoantibodies are found to have functional anti-FceRla and low or even borderline low CI INH levels, the cumulative effect may be significant, and although female patients with hypersensitivities and ANA may have anti-FceRIa less able to induce, "pronounced histamine-releasing activity," from basophils (according to one study), there seems to be a possible link between ANA and C1 INH deficiency and/or autoantibodies.
Thirdly, it downregulates FcIuRI on basophils,13 mast cells,14 and dendritic cells.
However, a complex reciprocal interaction was noted between endotoxin and smoking in the relationship to eosinophil and basophil counts (Table 3).
Also, sublethal concentrations of aluminium phosphide elicited effects on the haematological parameters of the fish such as a decrease in Hb when compared to the control; reduction of MCV, MCH and MCHC to all exposed concentration of aluminium phosphide, significant increase in neutrophil, basophil, eosinophil and monocytes throughout the duration of exposure and decrease in the lymphocytes.
3]/[micro]L Heterophils, % 71 [+ or -] 13 74 35-85 Lymphocytes, % 23 [+ or -] 12 21 6-55 Eosinophils, % 0 [+ or -] 0 1 0-1 Monocytes, % 0 [+ or -] 0 0 0-3 Basophils, % 0 [+ or -] 0 0 0-5 Heterophil: lymphocyte 3.
The low basophil and eosinophil counts in both sexes are consistent with previously calculated intervals (32), likely because of the low prevalence of parasitic infection in the Canadian population and the narrow range of environmental antigens.
Basophils originate from bone marrow and circulate in the blood; they are the least abundant white blood cells.
The product is a once-daily oral anti-Th2 therapy and has been indicated to block the recruitment and activation of Th2 lymphocytes, type 2 innate lymphoid cells, eosinophils and basophils and is presently in a Phase 2 study in patients with atopic dermatitis in leading centres throughout Europe.
Their activation is enhanced by basophils intervention in later stages of the allergic phenomena.
Because neutrophils and basophils cannot be separated using this approach, a second cytochemical channel was necessary for specifically measuring basophils.