base excision repair

(redirected from Base-excision repair)
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base excision repair

A mechanism that repairs damaged DNA during the cell cycle by removing small, non-helix-distorting nucleotide base lesions, which could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases that recognise and remove damaged or inappropriate bases, forming AP sites which are then cleaved by an AP endonuclease. The single-strand break formed by AP endonuclease are then processed by either short-patch (a single nucleotide is replaced), or long-patch (2–10 new nucleotides are synthesised) repair.
References in periodicals archive ?
Excision of the U residue from DNA produces an abasic site, leading to incision of the DNA strand containing the abasic site by the conventional base-excision repair pathway.
Abstract Title: Unexpected prolonged half life of the base-excision repair inhibitor methoxyamine given with temozolomide in the first-in-human phase 1 clinical trial