stratum germinativum

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Related to Basal cell layer: epidermis, stratum basale, stratum germinativum

stratum

 [stra´tum, strat´um] (L.)
a sheetlike mass of tissue; see also lamina and layer.
stratum basa´le the deepest layer of the epidermis, composed of a single layer of basophilic cells. Called also basal layer of epidermis.
stratum cor´neum the outer horny layer of the epidermis, consisting of cells that are dead and desquamating. Called also horny layer.
stratum germinati´vum
1. the stratum basalis and stratum spinosum considered together; called also malpighian layer.
2. the lower layer of the nail, from which the nail grows; called also germinative layer.
stratum granulo´sum the cell layer of the epidermis lying between the stratum lucidum and the stratum spinosum. Called also granular layer.
1. the deep layer of the cortex of the cerebellum.
2. the layer of follicle cells lining the theca of the vesicular ovarian follicle; called also granular layer.
stratum lu´cidum the clear translucent layer of the epidermis, just beneath the stratum corneum. Called also clear layer.
stratum spino´sum the layer of the epidermis between the stratum granulosum and stratum basalis, marked by the presence of prickle cells; called also spinous layer and prickle-cell layer.

strat·um ba·sa·le ep·i·derm·i·dis

the deepest layer of the epidermis, composed of dividing stem cells and anchoring cells.

stratum germinativum

stratum basale

; stratum germinativum; germinal layer; basal layer deepest layer of the epidermis lying at dermoepidermal junction, keratinocytes and melanosomes Table 1
Table 1: Constituents of skin
ConstituentComponents
EpidermisStratified squamous epithelium formed from keratinocytes
Basal layer: keratinocytes linked by desmosomal and hemidesmosomal and filamentous connections (cytoskeleton; prevents shear)
Spinous layer: keratinocytes shrink, retaining contact only at desmosomes and hemidesmosomes
Granular layer: keratinocytes secrete complex lipids which act as a semipermeable skin barrier
Corneal layer: cell and contents have become keratin to form squames moved towards the exterior
Epidermal cellsKeratinocytes
Melanocytes: lie between keratinocytes; secrete pigment and protect keratinocyte nuclei from ultraviolet radiation
Merkel cells: sensory cells
Langerhans cells: within spinous layer; antigen-presenting cells
Basement membrane zoneCollagen, hemidesmosomes, laminin which aid adhesion of epidermis to dermis; dysfunctional in disease such as epidermolysis bullosa
DermisMesodermal tissue containing blood vessels, nerve, muscle, skin appendages (sweat glands, sebaceous glands, hair follicles), immune cells (histamine-releasing mast cells) in a matrix of collagen, elastin and hyaluronic acid
Subcutaneous layerAdipose tissue, blood vessels and nerves, acting as an insulating layer

stratum

pl. strata [L.] a sheetlike mass of tissue of fairly uniform thickness; distinct layers making up various tissues or organs, as of the skin, brain, retina.

stratum avasculosum
the avascular stratum in the margin of the iris.
stratum basale
the mitotically active, basal layer of the epidermis, consisting of columnar to cuboidal keratinocytes on a basement membrane.
stratum corneum
the outer horny layer of the epidermis, consisting of cells that are non-nucleated, keratinized and desquamating.
stratum germinativum
in the epidermis, located between the stratum basale and the stratum granulosum. Together with the basal layer, called the malpighian layer. Called also germinative layer.
stratum granulosum
1. the layer of cells between the stratum lucidum and the stratum spinosum of the skin, very thin and not always present. Called also the granular layer.
2. the deep layer of the cortex of the cerebellum.
3. the layer of follicle cells lining the theca of the vesicular ovarian follicle. Called also granular layer.
stratum lamellatum
laminae of the hoof corium.
stratum lucidum
the translucent layer of the skin just beneath the stratum corneum. Called also clear layer. Present in the epidermis of the planum nasale of several species and footpads of carnivores.
stratum spinosum
the layer of the epidermis between the stratum granulosum and the stratum basale, marked by the presence of prickle cells; called also spinous layer and prickle-cell layer.
stratum tectorium
the layer of horny scales claimed to exist on the surface of the horse's hoof that gives it the smooth glossy appearance.
References in periodicals archive ?
Immunohistochemically (32) and ultrastructurally, (33) a basal cell layer with myoepithelial differentiation is demonstrable and is positive for S100, HHF-35, and HMWCK.
It is composed of 3 types of cells: (1) the basal cells, which are cylindrical to flat and in contact with the underlying fibroconnective tissue or lamina propria--the basal cell layer is thought to harbor urothelial stem cells; (2) the intermediate cells, which are cuboidal to columnar cells, overlie the basal cells, and usually have the same orientation toward the bladder lumen; and (3) the umbrella cells, which are larger flat eosinophilic cells, with ample pink cytoplasm and variable nuclear reactive/degenerative atypia such as binucleation, smudging, and nucleoli.
2 cell populations with central small and uniform nuclei and peripheral pleomorphic nuclei may be seen in dense cribriform and solid patterns Comedonecrosis May be present Basal cell layer Preserved, at least focally Table 2.
Traditionally, well-differentiated prostatic adenocarcinoma has been distinguished from benign glands by several well-accepted histologic criteria, including a small glandular proliferation with nuclear enlargement and prominent nucleoli, amphophilic cytoplasm, intraluminal crystalloids, and the absence of a basal cell layer.
5) However, the presence of a basal cell layer by nuclear staining with p63 and the absence of cytoplasmic staining with P504S would be helpful in differentiating this benign mimicker as well as seminal vesicle/ejaculatory duct epithelium from invasion by prostatic carcinoma.
48,49) Features of benign hyperplastic glands in comparison to pseudohyperplastic glands include lack of crowding, lack of association with usual acinar adenocarcinoma, benign-appearing nuclei, presence of a basal cell layer by H&E and IHC, and absence of AMACR staining.
A basal cell layer could be appreciated that was maintained around the deep glands and was highlighted uniformly by both p63 (Figure 2, B) and 34[beta]E12 (Figure 2, C).
2,3] This basal cell layer is believed to be absent in malignant epithelial lesions, but present in nonmalignant epithelial lesions.

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