Basal cell cancer


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Related to Basal cell cancer: melanoma, Squamous cell cancer

basal cell carcinoma

A usually indolent skin cancer that is most common in the sun-exposed regions of the head, neck and upper body in older individuals.
 
Management
Local excision; in areas where tissue border may compromise function or appearance (e.g., angle of eyes, eyelids, nose), Mohs surgery may be indicated.
 
Pathogenesis
Basal cell carcinomas appear to arise from two distinct cell types: interfollicular epidermal basal keratinocytes, which are hedgehog-driven tumours, and follicular epidermal basal keratinocytes, which arise from the so-called bulge stem.

Types
• Adenoid basal cell carcinoma.
• Basosquamous basal cell carcinoma.
• Cystic basal cell carcinoma.
• Fibroepithelial basal cell carcinoma.
• Infiltrating basal cell carcinoma.
• Infundibulo-cystic basal cell carcinoma.
• Keratotic basal cell carcinoma.
• Metatypical basal cell carcinoma.
• Micronodular basal cell carcinoma.
• Nodular (solid) basal cell carcinoma.
• Pigmented basal cell carcinoma.
• Sclerosing basal cell carcinoma.
• Superficial basal cell carcinoma.
• Adenomatoid basal cell carcinoma.
• Clear cell basal cell carcinoma.
• Follicular basal cell carcinoma.
• Giant cell basal cell carcinoma.
• Granular cell basal cell carcinoma.
• Pleomorphic basal cell carcinoma.
• Signet ring basal cell carcinoma.
• Basal cell carcinomas with adnexal differentiation (eccrine, apocrine and sebaceous).
• Basal cell carcinoma with matricial differentiation.
• Basal cell carcinoma with myoepithelial differentiation.
• Basal cell carcinoma with neuroendocrine differentiation.

Basal cell cancer

The most common form of skin cancer; it usually appears as one or several nodules having a central depression. It rarely spreads (metastisizes), but is locally invasive.
Mentioned in: Cryotherapy
References in periodicals archive ?
Their research shows that people with a history of squamous and basal cell cancers run a 35 percent risk of developing another tumor within three years and a 50 percent risk within five years.
Separately, Matrix reports that unanticipated findings in its preliminary analysis of data from contribution of component clinical trials in basal cell cancer will delay development of AccuSite in this indication.
Phase III testing for the treatment of basal cell cancer has commenced this year.
In addition to our upcoming Market Approval Authorization (MAA) and New Drug Application (NDA) submissions for AccuSite(TM) for genital warts, we are continuing Phase III testing of AccuSite(TM) for the treatment of basal cell cancer," he added.
Assuming favorable results in Phase III testing, the company plans to file a supplementary regulatory application for market approval for the treatment of basal cell cancer as a second indication for AccuSite pending receipt of market approval for genital warts.
NASDAQ/NMS:MATX), announced today that it has initiated Phase III trials of its AccuSite(TM) injectable gel for patients with basal cell cancer.
AccuSite injectable gel, the company's lead product, has completed Phase III testing for the treatment of genital warts and is expected to advance soon into Phase III clinical trials for the treatment of basal cell cancer.
They tend to be more aggressive than basal cell cancers and are more likely to be found in men than women.
While studies suggest that some easily treated skin cancers - squamous cell and basal cell cancers - can be caused by "prolonged and abusive over-exposure" to sunlight, even this kind of extreme over-exposure has been found to have nothing to do with the incidence or occurrence of cancerous melanoma.
Sanford has a significant family history of skin cancer and has already had squamous and basal cell cancers and a pre-melanoma.

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