Barrett esophagus


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Bar·rett syn·drome

(bar'ĕt),
chronic peptic ulceration of the lower esophagus, which is lined by columnar epithelium, resembling the mucosa of the gastric cardia, acquired as a result of long-standing chronic esophagitis; esophageal stricture with reflux, and adenocarcinoma, also have been reported. Associated with a 30-to-40 fold increased risk of adenocarcinoma.

Bar·rett syn·drome

, Barrett esophagus , Barrett metaplasia (bar'ĕt sin'drōm, ĕ-sof'ă-gŭs, met'ă-plā'zē-ă)
Chronic peptic ulceration of the lower esophagus, which is lined by columnar epithelium, resembling the mucosa of the gastric cardia, acquired as a result of long-standing chronic esophagitis; esophageal stricture with reflux, and adenocarcinoma, also have been reported.

Barrett,

Norman Rupert, English surgeon, 1903-1979.
adenocarcinoma in Barrett esophagus - an adenocarcinoma arising in the lower third of the esophagus that has become columnar cell lined (Barrett mucosa) due to gastroesophageal reflux.
Barrett epithelium - columnar esophageal epithelium seen in Barrett syndrome.
Barrett esophagus - chronic peptic ulceration of the lower esophagus acquired as a result of long-standing chronic esophagitis. Synonym(s): Barrett syndrome; Barrett ulcer
Barrett syndrome - Synonym(s): Barrett esophagus
Barrett ulcer - Synonym(s): Barrett esophagus
Eagle-Barrett syndrome - Synonym(s): prune belly syndrome

Bar·rett syn·drome

, Barrett esophagus , Barrett metaplasia (bar'ĕt sin'drōm, ĕ-sof'ă-gŭs, met'ă-plā'zē-ă)
Chronic peptic ulceration of the lower esophagus, which is lined by columnar epithelium, resembling the mucosa of the gastric cardia, acquired as a result of long-standing chronic esophagitis.
References in periodicals archive ?
Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia.
The utility of cytokeratins 7 and 20 (CK7/20) immunohistochemistry in the distinction of short-segment Barrett esophagus from gastric intestinal metaplasia: is it reliable?
Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus.
Immunohistochemical evaluation of a panel of tumor cell markers during malignant progression in Barrett esophagus.
Barrett esophagus is the most important risk factor for the development of esophageal adenocarcinoma.
Barrett esophagus is initiated by GERD, leading to reflux esophagitis with injury of the squamous epithelium.
The epidemiology of Barrett esophagus shows a male to female ratio of approximately 3:1.
Barrett esophagus cannot be detected on clinical grounds, as there are no specific symptoms of Barrett esophagus that distinguish this condition clinically from patients with GERD without Barrett esophagus.
Patients with Barrett esophagus developed esophageal cancer at an annual rate of 0.
Biopsy samples from the squamocolumnar junction of patients with Barrett esophagus show neutral mucin-containing columnar (cardiac-type) epithelium (Figure 1, A) with interspersed goblet cells (Figure 1, B).
Tissue fragments containing fundic (oxyntic) mucosa reflect sampling of the proximal stomach, such as a hiatal hernia, rather than metaplasia within the esophagus and, thus, should not be considered to represent Barrett esophagus.
Glickman et al (8) evaluated multilayered epithelium in samples obtained from 17 patients and found that its glandular cells expressed neutral mucins, sialomucins, and sulfomucins at rates comparable to Barrett esophagus (88%, 100%, and 71% of cases, respectively, versus 100%, 100%, and 76%, respectively).