adiposogenital dystrophy

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adiposogenital dystrophy

 [ad″ĭ-po-so-jen´ĭ-t'l dis´trah-fe]
increased body fat (obesity) accompanied by underdevelopment of the genitalia and altered secondary sex characteristics, caused by damage to certain parts of the hypothalamus, with a decrease in the secretion of gonadotropic hormones from the anterior lobe of the pituitary gland. Treatment depends on the primary cause of the condition, usually a tumor or infection involving the hypothalamus. Called also adiposogenital syndrome and Fröhlich's syndrome.

ad·i·po·so·gen·i·tal dys·tro·phy

a disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Vision loss, behavioral abnormalities, and diabetes insipidus may occur. Fröhlich syndrome is a common synonym for this disorder. Although the original case involved a pituitary tumor, most cases are thought to result from hypothalamic dysfunction in areas regulating appetite and gonadal development. The most common causes are pituitary and hypothalamic neoplasms.

adiposogenital dystrophy

[ad′ipō′sōjen′itəl]
Etymology: L, adeps + genitalis, generation
a disorder occurring in males, characterized by genital hypoplasia and feminine secondary sex characteristics, including female distribution of fat. It is caused by hypothalamic malfunction or by a tumor in the adenohypophysis. Hypothermia, hypotension, and hypoglycemia are frequently associated with the disorder. Diabetes insipidus also results from hyposecretion of antidiuretic hormone, which causes increased output of diluted urine, electrolyte imbalances, and thirst. In addition, involvement of the satiety center may induce overeating and result in pronounced obesity. If a tumor is present, there may be drowsiness and symptoms of increased intracranial pressure (for example, subtle locus of control changes and headache). Treatment may include the administration of testosterone and a weight-reduction program, excision or radiological ablation of a tumor, and replacement of hormones, as necessary. Also called adiposogenital syndrome, Fröhlich's syndrome.

dys·tro·phi·a ad·i·po·so·ge·ni·ta·lis

(dis-trō'fē-ă ad-i-pō'sō-jen-i-tā'lis)
A disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Visual loss, behavioral abnormalities, and diabetes insipidus may occur. The most common causes are pituitary and hypothalamic neoplasms.
Synonym(s): adiposogenital dystrophy, Fröhlich syndrome, hypophysial syndrome.

adiposogenital dystrophy

See FROHLICH'S SYNDROME.

dys·tro·phi·a ad·i·po·so·ge·ni·ta·lis

(dis-trō'fē-ă ad-i-pō'sō-jen-i-tā'lis)
Disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys.
Synonym(s): adiposogenital dystrophy, Fröhlich syndrome, hypophysial syndrome.

adiposogenital dystrophy, adiposogenital syndrome

a disease characterized by abnormal distribution of fat (obesity) accompanied by underdevelopment of the genitalia. The condition is caused by damage to certain parts of the hypothalamus, with a decrease in the secretion of gonadotropic hormones from the anterior lobe of the pituitary gland. Treatment depends on the primary cause of the condition, usually a tumor or infection involving the hypothalamus. Called also Fröhlich's syndrome.