CASC3

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CASC3

A gene on chromosome 17q11-q21.3 that encodes a widely expressed protein which is a core component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC marks the position of the exon–exon junction in the mature mRNA and thereby influences downstream processes of gene expression, including mRNA splicing, nuclear mRNA export, subcellular mRNA localisation, translation efficiency and nonsense-mediated mRNA decay. It interacts with EIF4A3, MAGOH, NXF1 and RBM8A, as well as with STAU in an RNA-dependent fashion.
 
Molecular pathology
CASC3 is overexpressed in the breast and in gastric cancers.
References in periodicals archive ?
These analyses were used to identify and characterize macroinvertebrate community types in the BTZ.
Environmental variables were again overlaid as vectors to help determine which factors were important in influencing waterfowl distribution on BTZ wetlands.
Amphipoda continued to dominate the macroinvertebrate communities of BTZ wetlands, with Hyalella and Gammarus accounting for 45 and 25% of all macroinvertebrates collected, respectively.
Molting waterfowl surveys identified 14 duck species using BTZ wetlands (7 dabbling ducks and 7 diving ducks) with an average of 81.
There was little temporal stability in macroinvertebrate communities within the BTZ wetlands that we sampled.
As was observed during the breeding period, macroinvertebrate community types were not good predictors of individual waterfowl species on BTZ wetlands, but there was a significantly positive relationship between overall molting waterfowl abundance and macroinvertebrate abundance ([R.
We documented 5 distinct aquatic macroinvertebrate communities in the BTZ wetlands sampled in this study including: Amphipoda-dominated communities (MC1 and AC1); Diptera-dominated communities (MC2); Notonecta-dominated communities (AC2); Sigara-dominated communities (MC3); and Chaoborus-Sigara-dominated communities (AC3).
Because aquatic macroinvertebrate communities have never previously been described in the BTZ of western Canada, our main objective was to provide an initial description of these communities along a gradient in agricultural encroachment.
However, further research is required to determine whether Sigara-dominated communities can be consistently used as indicators of enriched and agriculturally impacted wetlands in the BTZ.
12) Here it was clearly shown that HPT outperformed BTZ in most automotive applications.
Based on these results, it is apparent that the used triazine HPT-4 chromophores significantly outperform the conventional BTZ in terms of photopermanence.
16) In general, reactive UVAs outperform nonreactive UVAs, and reactive HPTs show improved performance compared with reactive BTZs.