ABCB11

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ABCB11

A gene on chromosome 2q24 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance and is major canalicular bile salt export pump
Molecular pathology ABCB11 mutations cause a type of progressive
familial intrahepatic cholestasis of early (infancy) onset.
References in periodicals archive ?
Immunohistochemistry for BSEP was performed using a monoclonal mouse anti-human antibody BSEP clone F-6 (Santa Cruz Biotechnology, Santa Cruz, California) at 1:200 dilution.
For pCEA and BSEP, a canalicular staining pattern was considered positive (Figure 1, A and B); membranous or luminal positivity without canalicular staining was considered negative.
lt;<Informe del Departamento de Bellas Artes, 16 de diciembre de 1930 a 28 de febrero de 1931>>, BSEP, tomo X, no.
BSEP, 2 (1847), 5-22, especially 14-17; also NAV 5th serie, 10 (1847), 299-318; 9 (1847), 326-67.
e] serie, 10 (1847), 238, 377-78, 386-87 and 11 (1847), 237-38; BSEP, 2 (1847), 96, 173.
In the present study, the potential of miroestrol and deoxymiroestrol to modify the hepatic enzymes involved in bile salt transportation including BSEP and MRP2, were examined in comparison with estradiol.
The forward and reverse primers and the product size of the genes were as follows: (1) BSEP, 5'-CAC ACA AAG CCC CTA CCA GT-375'-CCA GAG GCA GCT ATC AGG AC-3', 231 bp; (2) MRP2, 5'-GCA CTG TAG GCT CTG GGA AG-3'/5'-CAT UC CAA GTC TGG GAG GA-3', 224 bp; and (3) GAPDH, 5'-TCC ACT CAC GGC AAA TTC AAC G/TAG ACT CCA CGA CAT ACT CAG C-3', 145 bp.
Not all children with BSEP deficiency will develop cancer, but those who did develop the cancer all carried the faulty gene, the researchers said.
The BSEP is a coalition of organisations with energy interests including Birmingham City Council, Energywatch, Hestia, EAGA partnership, Groundwork, Factor 4, NEA, Environment Agency and Climate Change Solutions.
Mr Mitchell said: "I look forward to continuing to work together with Phil Beardmore, BSEP, local businesses and the local community towards a cleaner, greener Sutton Coldfield.
Under BSEP, private bus operators are being roped in to supplement the services of public transport operators to smoothen peak hour congestion and waiting time.
The statement has further revealed that the BSEP has facilitated overhaul 93 bus services and added that commuters in several areas of Singapore are likely to witness superior service.