ABCB11

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ABCB11

A gene on chromosome 2q24 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance and is major canalicular bile salt export pump
Molecular pathology ABCB11 mutations cause a type of progressive
familial intrahepatic cholestasis of early (infancy) onset.
References in periodicals archive ?
e] serie, 10 (1847), 238, 377-78, 386-87 and 11 (1847), 237-38; BSEP, 2 (1847), 96, 173.
433, 436; BSEP, 1 (1846), 102; 2 (1847), 173, 288; NAV, [5.
e] 10 (1847), 378, 386; 11 (1847), 237; 12 (1847), 119-20; BSEP, 2 (1847), 85-90, 96, 173, 238.
e] 11 (1847), 86-87, 91, BSEP, 2 (1847), 85, 92, 121, 126.
e], 7 (1846), 357 and 8 (1846), 228; BSEP, 1 (1846), 81.
The forward and reverse primers and the product size of the genes were as follows: (1) BSEP, 5'-CAC ACA AAG CCC CTA CCA GT-375'-CCA GAG GCA GCT ATC AGG AC-3', 231 bp; (2) MRP2, 5'-GCA CTG TAG GCT CTG GGA AG-3'/5'-CAT UC CAA GTC TGG GAG GA-3', 224 bp; and (3) GAPDH, 5'-TCC ACT CAC GGC AAA TTC AAC G/TAG ACT CCA CGA CAT ACT CAG C-3', 145 bp.
Mouse MRP2, BSEP, and GAPDH mRNAs were semi-quantified by RT-PCR.
BSEP and MRP2 are major transporters in the canalicular bile salt export pump and its conjugate.
In conclusion, miroestrol and deoxymiroestrol showed inhibitory potential on the mRNA expression of BSEP and MRP2, hepatic enzymes that are involved in the excretion of bile acid.
Mr Mitchell said: "I look forward to continuing to work together with Phil Beardmore, BSEP, local businesses and the local community towards a cleaner, greener Sutton Coldfield.
However, the number reflects just around 25% of the 550 extra buses pledged under the BSEP of the Government.