BRCA1

(redirected from BRCAI)
Also found in: Dictionary, Wikipedia.

BRCA1

symbol for a breast cancer gene. BRCA1 is a tumor suppressor gene. A healthy BRCA1 gene produces a protein that protects against unwanted cell growth. The protein is packaged by the cell's Golgi apparatus into secretory vesicles, which release their contents on the cell's surface. The protein circulates in the intracellular space, attaching itself to neighboring cell receptors. The receptors signal the cell nuclei to stop growing. When the gene is defective, it produces a faulty protein that is unable to prevent proliferation of abnormal cells as they evolve into potentially deadly breast cancer. BRCA1 may also normally inhibit ovarian cancer.

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
The risk for breast cancer was significantly lower in BRCA2 patients, compared with BRCAI patients.
BRCAI testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and outcomes.
Natasha says she has already decided she will have a double mastectomy if she has the BRCAI gene.
I went for genetic testing became my mother tested positive for the BRCAI gene after having breast cancer in her mid-30's and ovarian cancer in her 50's.
1% of 1,072 breast cancer patients from highly breast cancer--prone families that did not carry BRCAI or BRCA2 mutations.
The effort required sequencing the entire BRCAI and BRCA2 genes--approximately 24,000 base pairs--to be sure they could identify every possible mutation.
In a study involving 175 women who had breast cancer but had not yet started treatment, 124 chose to be tested and 21 of those were found to carry BRCAI or BRCA2 mutations, which have been found to increase greatly the chance of a new primary breast cancer either in the contralateral or ipsilateral breast.
In a study of 60 patients with a BRCAI mutation who underwent the procedure at about 48 years of age, 5 patients already had the disease.
That's because there are no good data on the prevalence of individual breast cancer risk factors--including menarche younger than 12, first birth after age 30, the finding of atypical hyperplasia on breast biopsy, a positive family history, or a BRCAI or BRCA2 mutation--among nonwhites.
Although promising, the results are not enough to recommend prophylactic oophorectomy to women with BRCAI mutations, Dr.
135-1G>T Full length + + [DELTA]5q (d) + + [DELTA]5 (d) + + [DELTA]3 (d) - + [DELTA]3,5 (d) - + [DELTA]5,6 (d) - + ins i3 (d) - + Ins i3-[DELTA]5 (d) - + BRCAI c.
She made the choice after receiving genetic test results that indicated she carries a mutation on her BRCAI gene that significantly increases the risk of some types of breast or ovarian cancer.