The risk for breast cancer was significantly lower in BRCA2 patients, compared with BRCAI
testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and outcomes.
Natasha says she has already decided she will have a double mastectomy if she has the BRCAI
I went for genetic testing became my mother tested positive for the BRCAI
gene after having breast cancer in her mid-30's and ovarian cancer in her 50's.
1% of 1,072 breast cancer patients from highly breast cancer--prone families that did not carry BRCAI
or BRCA2 mutations.
The effort required sequencing the entire BRCAI
and BRCA2 genes--approximately 24,000 base pairs--to be sure they could identify every possible mutation.
In a study involving 175 women who had breast cancer but had not yet started treatment, 124 chose to be tested and 21 of those were found to carry BRCAI
or BRCA2 mutations, which have been found to increase greatly the chance of a new primary breast cancer either in the contralateral or ipsilateral breast.
In a study of 60 patients with a BRCAI
mutation who underwent the procedure at about 48 years of age, 5 patients already had the disease.
That's because there are no good data on the prevalence of individual breast cancer risk factors--including menarche younger than 12, first birth after age 30, the finding of atypical hyperplasia on breast biopsy, a positive family history, or a BRCAI
or BRCA2 mutation--among nonwhites.
Although promising, the results are not enough to recommend prophylactic oophorectomy to women with BRCAI
135-1G>T Full length + + [DELTA]5q (d) + + [DELTA]5 (d) + + [DELTA]3 (d) - + [DELTA]3,5 (d) - + [DELTA]5,6 (d) - + ins i3 (d) - + Ins i3-[DELTA]5 (d) - + BRCAI
She made the choice after receiving genetic test results that indicated she carries a mutation on her BRCAI
gene that significantly increases the risk of some types of breast or ovarian cancer.