BRCA2


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Related to BRCA2: BRCA1

BRCA2

symbol for a breast cancer gene with activity similar to that of BRCA1.

BRCA2

A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.

BRCA2

Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
References in periodicals archive ?
TATs for BRCA1 and BRCA2 testing in our laboratory in Nijmegen have varied over the years, depending on the respective test performed (denaturing gradient gel electrophoresis in combination with protein truncation test; Sanger sequencing; AmpliSeq/IonTorrent PGM, smMIP/NextSeq500).
In contrast, most BRCA2 carcinomas in the present study were associated with hormonal receptor and HER2 positive; our results are in good concordance with those obtained by [27].
Un estudio de cohorte en individuos con mutaciones BRCA1-BRCA2, realizado en el 2013 en Reino Unido (N = 1887), determino que el riesgo acumulado para los 70 anos de desarrollar cancer de seno u ovario fue de entre 59 y 60% para BRCA1 y de y 16,5 a 55% para BRCA2 respectivamente.
It was logical to imagine that since BRCA1 and BRCA2 were prototypical DS DNA repair genes, it should be possible to discern global patterns of changes in the DNA of tumors that would not only include the observed BRCA deficiencies but would extend beyond known territory to encompass functionally similar causative defects.
The results, published in the journal Nature Genetics, open up the possibility of personalised treatment for lung cancer patients with BRCA2 mutations.
BRACA (bra-h) refers to BRACAnalysis, Myriad Genetics' test for BRCA1 and BRCA2.
The court emphasized the narrow scope of its ruling, which concerned patents related to the BRCA1 and BRCA2 genes found to be associated with higher incidence of breast and ovarian cancer in women.
In normal cells, the genes BRCA1 and BRCA2 help ensure the stability of the cell's DNA and help prevent uncontrolled cell growth.
Prostate cancer spreads more quickly and is more likely to be fatal in men with a defective BRCA2 gene, a study found.
We previously estimated that about 2% of PrCa cases diagnosed [less than or equal to] 55 years harbour a BRCA2 mutation and PrCa among BRCA2 carriers has been shown to be more aggressive, with poorer survival.