BRCA2


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Related to BRCA2: BRCA1

BRCA2

symbol for a breast cancer gene with activity similar to that of BRCA1.

BRCA2

A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.

BRCA2

Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
References in periodicals archive ?
The clinical laboratory assay has been hardened so that robust results are obtained on formalin fixed paraffin embedded (FFPE) pathology tissue with BRCA1 and BRCA2 exon sequences and genome wide quantitative SNP data generated by next generation sequencing.
Although mostly associated with women's cancers, defective BRCA2 can raise a man's lifetime risk of prostate cancer by up to 25%.
The scientists analysed BRCA2 in blood samples of almost 2,000 prostate cancer patients to achieve their results.
Patient 2 had a BRCA2 mutation after he was diagnosed with invasive ductal carcinoma of the breast at age 58.
BSO was associated with a significantly decreased risk of breast cancer in those without prior breast cancer with both BRCAI (37% reduction) and BRCA2 mutations (64% reduction).
The same process involving BRCA2 can lead to hereditary breast cancer in
Worldwide many families with a strong history of familial breast cancer have been fully screened for BRCA1 and BRCA2 mutations but none were found.
For the majority of families who do not harbour BRCA1 or BRCA2 mutations, it is considered likely that a number of genetic factors, each with a small cumulative contribution, are responsible.
Five to 10 per cent of breast cancer patients have an inheritable form of breast cancer due to a mutation in BRCA1 or BRCA2.
The researchers studied tumor cells containing a faulty version of the breast cancer gene BRCA2.
The mother of two carries a fault in the BRCA2 gene and could benefit from the ground-breaking research in the future.