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BRCA2

   Also found in: Acronyms, Wikipedia 0.01 sec.
BRCA2 (bär-s-t)
n.
A tumor suppressor gene that, when inherited in a mutated state, is associated with the development of various cancers, especially breast and ovarian cancer.
BRCA2,
symbol for a breast cancer gene with activity similar to that of BRCA1.
BRCA2
Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.


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The genes, called BRCA1 and BRCA2, normally encode proteins that suppress rampant cell growth.
Defect detector: plugging holes in a breast cancer-gene screen by Seppa, N. / Science News
The oncogenes c-myc, c-met, k-ras and the neoplastic progression protein-3 (Npn3) were also increased 2- to 3-fold in arsenic-induced HCC and nontumorous, normal liver from arsenic exposed mice, while the tumor suppressors BRCA1 and BRCA2 decreased 30-50%.
Global gene expression associated with hepatocarcinogenesis in adult ... by Waalkes, Michael P. / Environmental Health Perspectives
Researchers already know that mutations on two genes, called the BRCA1 and BRCA2, significantly increase a woman's risk of the disease.
Women & living with breast cancer today by National Women's Health Report
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