BAP1

(redirected from BRCA1-associated protein 1)

BAP1

A gene on chromosome 3p21.31-p21.2 that encodes a tumour-suppressing enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. BAP1 forms the catalytic component of the PR-DUB complex, which specifically mediates deubiquitination of histone H2A monoubiquitinated at “Lys-119”. BAP1 is also a less preferred gene symbol for what is now designated as MAGI1, see there.
References in periodicals archive ?
BRCA1-associated protein 1 (BAP1) is a nuclear ubiquitin hydrolase that is believed to function as a tumor suppressor.
Nasu et al, (31) 2015 (a) 9/16 (56) 5/8 (63) Farzin et al, (36) 2015 19/42 (45) 12/67 (18) Yoshikawa et al, (37) 2012 1/5 (20) Sheffield et 2/12 (15) al, (39) 2015 (b) Cigognetti et al, (38) 2015 9/15 (60) 2/13 (15) Abbreviation: BAP1, BRCA1-associated protein 1.
Nasu et al, (31) 2015 (a) 9/16 (56) 5/8 (63) Farzin et al, (36) 2015 19/42 (45) 12/67 (18) Yoshikawa et al, (37) 2012 1/5 (20) Sheffield et al, (39) 2015 (b) 2/12 (15) Cigognetti et al, (38) 2015 9/15 (60) 2/13 (15) Abbreviation: BAP1, BRCA1-associated protein 1.