DST

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DST

abbreviation for dexamethasone.

DST

A gene on chromosome 6p12.1 that encodes dystonin, a cytoskeletal linker protein which integrates intermediate filaments, actin and the microtubule cytoskeleton network, and is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional reticulum.

DST isoform 3 plays a structural role in assembling hemidesmosomes of epithelial cells; it anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes and is required for regulating keratinocyte polarity and motility; it mediates integrin ITGB4 regulation of RAC1 activity. DST isoform 6 is required for bundling actin filaments around the nucleus. DST isoform 7 regulates the organisation and stability of the microtubule network of sensory neurons to allow axonal transport.

Molecular pathology
Defects of DST cause hereditary sensory and autonomic neuropathy type 6.
References in periodicals archive ?
Experimental bullous pemphigoid generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230.
Thoma-Uszynski S, Uter W, Schwietzke S, Schuler G, Borradori L, Hertl M: Autoreactive T and B cells from bullous pemphigoid (BP) patients recognize epitopes clustered in distinct regions of BP180 and BP230.
Otoimmun bulloz hastaliklarda basilica hedef antijenler ve serum otoantikor tipleri Otoimmun bulloz Hedef antijen Otoantikorlar dermatoz Pemfigus foliaseus Dsq 1 Pemfigus vulgaris Dsg3 ve 1, IgG1, IgG4, IgE desmokollin, desmoplakin Paraneoplastik Dsg3 ve 1, pemfigus plakinler, BP180, BP230, 210 kDa, 170 kDa antijen Bulloz pemfigoid BP180, BP230 IgG1, IgG4, IgE Pemfigoid BP180, BP230 IgG1, IgG3 gestasyones Sikatrisyel BP180, [beta]4 IgG4, IgA pemfigoid integrin, laminin 5/6 Lineer IgA hastaligi Kollajen VII, BP180, IgA1, IgA4, IgG BP230, 97kDa, 120kDa, 285kDa antijen Dermatitis Epidermal IgA herpetiformis transglutaminaz Edinsel Kollajen VII IgG epidermolizis bulloza