BMPR2

(redirected from BMR2)
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BMPR2

A gene on chromosome 2q33-q34 that encodes a member of the bone morphogenetic protein (BMP)-receptor family of transmembrane serine/threonine kinases, which binds BMPs and plays a central role in endochondral bone formation and embryogenesis. Type-II receptors bind ligands in the absence of type-I receptors, but require their respective type-I receptors for signalling. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate then bind and activate SMAD transcriptional regulators.

Molecular pathology
BMPR2 mutations are associated with familial and fenfluramine-associated primary pulmonary hypertension and with pulmonary venoocclusive disease.
References in periodicals archive ?
Two cores, KL2 and BMR2, from the Bang Pakong Valley were analysed for phytoliths.
Fourteen samples were analysed from the BMR2 core, and 13 of these contained phytoliths in quantifiable concentrations.
Two phytolith sequences from the Bang Pakong Valley, Thailand: Cores KL2 and BMR2, in Thompson (in press).