BMPRIB

BMPRIB

A gene on chromosome 4q22-q24 that encodes a member of the type-I bone morphogenetic protein (BMP)-receptor family of transmembrane serine/threonine kinases, which binds BMPs and plays a central role in endochondral bone formation and embryogenesis. Type-I receptors require their respective type-II receptors for ligand binding. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate then bind and activate SMAD transcriptional regulators.

Molecular pathology
BMPRIB mutations are associated with primary pulmonary hypertension and brachydactyly type 2A.
References in periodicals archive ?
The disulfide-linked mature dimer of BMPs will associate with membrane receptors that have been identified as type I receptors--BMPRIA (or activin receptor-like kinase 3--ALK3) and BMPRIB (or ALK6), and type II receptor--BMPRII (Yamashita et al.
Studies of BMPRIB and BMP15 as candidate genes for fecundity in little tailed han sheep.
Recent studies demonstrated that interaction of BMPRIB and BMPRII elicits BMP15 biological activity (Moore et al.
Moreover, there have been few reports on the influence of expression of BMPRII, BMPRIB and ALK5 by daidzein in ovine granulosa cells.
Genes for BMPRII, BMPRIB, ALK-5 and GAPDH were quantified by real-time PCR with an iCycler iQ (Bio-Rad, Inc.
To determine whether daidzein regulated expression of BMPRII, BMPRIB and ALK-5 transcriptionally, granulosa cells were treated with 1-100 ng/ml of daidzein for 48 h.
The expression of BMP-15, GDF-9, and BMPRIB has been observed in sheep ovary.
The results indicated that daidzein (10-100 ng/ml) caused a significant increase in BMPRII, BMPRIB and ALK-5 mRNA.
Association of single nucleotide polymorphisms in exon 6 region of BMPRIB gene with litter size traits in sheep.
The type I BMP receptor BMPRIB is essential for female reproductive function.
In this study, we cloned a partial chicken BMPRIB gene, which corresponded to the ovine BMPR-IB exon 6 to exon 7 fragment including the Q249R mutation nucleotide, identified and investigated two single nucleotide polymorphisms (SNPs) in five chicken breeds (lines) and analyzed their associations with egg production traits in a synthetic broiler line.