A gene on chromosome 20q13 that encodes bone morphogenetic protein-7, which plays a key role in cartilage formation, osteoblast differentiation, renal development and repair, and induces the production of SMAD1.
GDF11, GDF8, inhibin and BMP7 were selected and sequences of ten same animals for each family were retrieved from GenPept.
Gorilla gorilla gorilla of both inhibin and BMP7 groups has displayed some interesting observation as it is emerging out from rest of its respective clades and showing its distant evolutionary relationships with other proteins of its class.
Previously, Ember announced the licensing of technology to several biologics including irisin and BMP7, and has secured licensing to several functional/pathway screens that are key to its brown fat pipeline, including PRDM16 and Foxc2.
Yu-Hua Tseng and Aaron Cypess, have performed pioneering work in this field over the past several years, and were the first to show that a natural protein called BMP7 can help modulate the levels of brown fat.
He also will disclose new data on the cell lines: SK17 that have the potential to differentiate into cells that express renin and smooth muscle cell-related genes characteristic of the juxtaglomerular apparatus of the kidney, Z2 that when differentiated using a proprietary protocol expresses relatively high levels of the bone growth factor genes BMP2 and BMP7 (also known as osteogenic protein-1 (OP-1), and J16 that expresses preadipocyte markers of interest to researchers in cosmetic dermatology and type II diabetes.