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In this research we sequenced Markhoz BMP15 gene exons and found three single nucleotide mutations.
Analyzed relationship between CLPG, BMP15 gene polymorphic and production performance of seven sheep populations in north of Xinjiang.
Three transforming growth members, BMPR-IB, BMP15, and GDF9, are the major genes of high prolificacy.
The BMP15 gene of sheep is located in the X chromosome.
2009) have been identified in the BMP15 gene, each having a major effect on prolificacy.
The 134 Baluchi ewes which had least one record for litter size were screened for GDF9, BMP15 and BMP15-1B mutations in the present study.
It is reported that the point mutations of BMP15 (Fec [X.
Recent studies demonstrated that interaction of BMPRIB and BMPRII elicits BMP15 biological activity (Moore et al.
1991) and can also be modulated by BMP15 which is produced by the oocytes (Sun et al.
Until now, the association of BMP15 exon 2 genetic variations with ovulation rate and litter size has been reported in some sheep breeds but not in the Arabic sheep.
In a family affected by hypergonadotropic ovarian failure, a mutation in the pro-region of the BMP15 gene (Y235C) was found in 2 affected sisters (1), and 3 linked markers within the BMP15 gene (-673C>T, -9C>G and IVS1 + 905A>G) are associated with high follicle production in women undergoing recombinant FSH stimulation (2).
The mRNA expression of cytoplasm maturation marker genes (MOS, BMP15, GDF9, and CCNB1) was analyzed by real-time RT-PCR (Figure 3B).
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- BMP type-1A receptor
- BMP type-1A receptor, ALK3
- BMP type-1B receptor
- BMP type-2 receptor
- BMP type-II receptor
- BMP2-induced 3-kb gene protein