BMP10

BMP10

A gene on chromosome 2p13.3, bone morphogenetic protein-10, which plays a key role in trabeculation of the embryonic heart, acting via receptor serine/ threonine kinases.
References in periodicals archive ?
BMP1 - 8p21; BMP2 - 20p12; BMP3 - 14p22; BMP4 - 14q22-q23; BMP5 - 6p12,1; BMP6 - 6p12,1; BMP7 - 20q13; BMP8a - 1p35p32; BMP8b - 1p35-p32; BMP10 - 2p14; BMP15 - Xp11,2.
Dalantercept (ACE-041) is an investigational protein therapeutic that inhibits angiogenesis by preventing BMP9 and BMP10, proteins in the TGF- superfamily, from interacting with activin receptor-like kinase 1 (ALK1), a cell-surface receptor found on proliferating vascular endothelial cells.
Dalantercept is an ALK1 receptor fusion protein that binds to BMP9 and BMP10 and inhibits their signaling through the ALK1 receptor.
ACE-041 is an ALK1 ligand trap that inhibits angiogenesis by preventing BMP9 and BMP10, members of the TGF protein superfamily, from interacting with activin receptor-like kinase 1 (ALK1), a receptor found on proliferating endothelial cells.
ACE-041 is a recombinant receptor fusion protein that inhibits angiogenesis by preventing BMP9 and BMP10, proteins in the TGF superfamily, from interacting with activin receptor-like kinase 1 (ALK1), a cell-surface receptor found on proliferating endothelial cells.