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BMP-2, BMP-4, BMP-7, and BMP-9 expression was significantly increased at the messenger RNA level in quadriceps of mice that underwent SCI (Figures 6-7).
However, BMP-4 transcripts are detected in the mesoderm around the developing gut and the myocardium (2).
Chronic BMP-4 infusion was showed to impair endothelium dependent vasodilatation in mice.
Compared to 1st generation DBM products, the AccellRx process on which Connexus is based yields a higher level of TGF- beta1 and nhBMPs, including BMP-2, BMP-4 and BMP-7, which act synergistically to stimulate new bone formation.
Recombinant BMP-4, a member of the BMP superfamily was also tested on primitive cells.
In conjunction with the product's launch, the company announced that an independent study by the Sepulveda Research Corporation, which is affiliated with the Department of Veterans Affairs Greater Los Angeles Healthcare System, demonstrates the presence of BMP-2, BMP-4 and TGF-EAA1 in its Accell(R) product family at significantly higher levels than in first generation demineralized bone matrix (DBM) derived products.
The Accell technology delivers significantly more of BMP-2, BMP-4 and TGF-EAA1 than first generation DBM products, and fully capitalizes on the acknowledged synergies between bone morphogenetic proteins.