BMP4

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BMP4

A gene on chromosome 14q22-q23 that encodes bone morphogenetic protein-4, which plays a key role in formation of teeth, limbs and bone from mesoderm, as well as fracture repair.
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Other claims provide for growth factors such as BMP-2, BMP-4, BMP-6, BMP-7, transforming growth factor (TGF-?
BMP-2, BMP-4, BMP-7, and BMP-9 expression was significantly increased at the messenger RNA level in quadriceps of mice that underwent SCI (Figures 6-7).
However, BMP-4 transcripts are detected in the mesoderm around the developing gut and the myocardium (2).
Chronic BMP-4 infusion was showed to impair endothelium dependent vasodilatation in mice.
Recombinant BMP-4, a member of the BMP superfamily was also tested on primitive cells.