BMP15

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BMP15

A gene on chromosome Xp11.2 that encodes bone morphogenetic protein 15, which is thought to play a role in oocyte and follicular development.
References in periodicals archive ?
Using the knockout mouse model, it has been proven that NOBOX regulates different gene expressions specific for the oocyte, including BMP-15 and GDF-9(31).
They are responsible for the follicle early growth and differentiation by control of a number of genes including NOBOX, FIGLA, BMP-15 and GDF-9(12).
It was shown that supplementation of culture media with BMP-15 maintained the ultrastructural integrity of isolated caprine pre-antral follicles and promoted the growth of pre-antral follicles cultured for seven and 18 days (13, 20, 21).
Integral role of GDF-9 and BMP-15 in ovarian function.
GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility.
A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse.
BMP-15 es expresado principalmente en el ovocito y reconocido por receptores BMPRIB (ALK6) en las celulas de la teca y del cumulus [11, 13, 16].
These results showed that BMP-15 gene is a genetic marker and closely linkage to the litter size trait and consequently can be used as a marker-assisted selection (MAS) for high litter size productivity in sheep.
The two genes GDF-9 and BMP-15 have made their sources in oocytes (Juengel et al.
In mammals BMP-15 is the product of an X-linked gene expressed in oocytes (Dube et al.
Unfortunately, in our study, no indication was found for under-expression of BMP-15 or GDF-9, since cumulus expansion is necessary for a proper oocyte development (Zhang et al.
Members of each subgroup (BMP-2, BMP-4, BMP-6, BMP-7, BMP-15, and growth differentiation factor-9(GDF-9)) have been shown to affect ovarian folliculogenesis, follicular growth and differentiation, cumulus expansion, ovulation and luteinization (Knight and Glister, 2006).