LTB4R

(redirected from BLT1)

LTB4R

A gene on chromosome 14q11.2-q12 that encodes a low-affinity G protein-coupled receptor for leukotrienes, including leukotriene B4. LTB4R mediates chemotaxis of granulocytes and macrophages by activating a phosphatidylinositol-calcium second messenger system. It is highly expressed in the heart, skeletal muscle and lymphoid tissue.
References in periodicals archive ?
Inhibition of atherogenesis in BLT1 -deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
We found strong statistically significant differences between the methylation status of PTGS2 and BLT1 in sera from pregnant women (n = 59) vs healthy controls (n = 10; P <0.
With this proof-of-principle study we show for the first time that methylation changes in TIMP-3, CDH1, PTGS2, BLT1, APC, and RASSFIA can be detected in pregnant women.