BLOSUM


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BLOSUM

Blocks Substitution Matrix. A substitution matrix in which scores for each position are derived from observations of the frequencies of substitutions in blocks of local alignments in related proteins.

Sequences that are more identical than 62% are represented by a single sequence in the alignment, to avoid over-weighting closely related family members.
References in periodicals archive ?
BLAST uses a scoring matrix such as PAM or BLOSUM to calculate an alignment score, which measures the significance of sequence similarity between any two sequences.
The BLOSUM matrices, proposed by Steven Henikoff y Jorja G.
In future work, additional experimentation should be performed, including experimentation with sequences of nucleic acids, the use of other algorithms to find initial sequence alignments and the use of other scoring schemes based on PAM or BLOSUM matrices.