PRDM1

(redirected from BLIMP1)

PRDM1

A gene on chromosome 6q21 that encodes a protein which represses beta-interferon gene expression, by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. PRDM1 transcription increases in response to viral induction.
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Asi mismo se han descrito otras alteraciones como amplificacion 19q, delecion del locus tumor supresor INKa/ARF, trisomia 3, inactivacion del tumor supresor BLIMP1 y la sobreexpresion de la familia de kinasas serina/treonina PIM, en relacion con los LBDCG fenotipo ABC (9).
BLIMP1 regulates cell growth through repression of p53 transcription.