BK virus


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Related to BK virus: Polyomavirus

BK vi·rus

a human polyomavirus, in the family Papovaviridae, of worldwide distribution, that produces kidney infections that are usually subclinical in immunocompetent people.
[initials of patient from whom first isolated]

BK virus

A small human polyomavirus which, like the JC virus, can transform infected cells in culture; up to 80% of the general population (US) have been exposed to it.

Clinical findings
Primary BKV infection is usually subclinical, most common in early childhood, persists in renal epithelium and may become reactivated, causing severe tubulointerstitial nephritis, and cystitis in BM transplant recipients or in immunocompromised patients—e.g., those with hyper-IgM immunodeficiency syndrome; BKV may cause encephalitis.
 
Diagnosis
Serology—IgM, IgG antibodies; PCR; T2-weighted MRI.

BK virus

Infectious disease A small human polyomavirus which, like the JC virus, can transform infected cells in culture; 1º BKV infection is usually subclinical, is most common in early childhood, persists in renal epithelium and may be reactivated, causing severe tubulointerstitial nephritis, and cystitis in BM transplant recipients, or in the immunocompromised Pts–eg, those with hyper-IgM immunodeficiency syndrome; BKV may cause encephalitis Diagnosis Serology–IgM, IgG antibodies; PCR, T2-weighted MRI. See Polyomavirus. Cf JC virus.
References in periodicals archive ?
Detection of BK virus and JC virus in urine and brain tissue by the polymerase chain reaction.
Clinically, however, renal involvement in the absence of the central nervous system symptoms favors BK virus infection.
As we progress CMX001 into a Phase 3 study for the prevention of cytomegalovirus infection in adults undergoing hematopoietic stem cell transplantation, these data support our desire to conduct additional clinical studies to evaluate the potential benefit of CMX001 against other double-stranded DNA viruses, including BK virus.
Longitudinal analysis of levels of immunoglobulins against BK virus capsid proteins in kidney transplant recipients.
This panel is a key tool for laboratories in optimizing molecular BK virus assay performance and will ultimately improve the management of transplant patients," says Michael J.
Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors.
CMX001 is a novel, broad-spectrum, oral antiviral that inhibits dsDNA viruses, including CMV, AdV, BK virus and herpes simplex virus.
This new retrospective analysis focuses on BK virus and shows that CMX001 may prevent end-organ damage in subjects who had BKV infection in the urine upon initiation of therapy.
In addition to Aspergillus Galactomannan EIA and Fungitell -D Glucan, the company offers tests for infectious diseases including BK Virus (BKV), JC Virus (JCV), Epstein-Barr Virus (EBV), and Cytomegalovirus (CMV).
Although BK virus, JC virus, and simian virus 40 are tumorigenic in experimental animals and can transform mammalian cells in vitro, no convincing epidemiologic evidence exists for their role in human cancers.
Other tests the company offers include quantitative molecular diagnostic tests for BK Virus (BKV), JC Virus (JCV), Epstein-Barr Virus (EBV), and Cytomegalovirus (CMV).