BK virus

(redirected from BK polyomavirus)

BK vi·rus

a human polyomavirus, in the family Papovaviridae, of worldwide distribution, that produces kidney infections that are usually subclinical in immunocompetent people.
[initials of patient from whom first isolated]

BK virus

A small human polyomavirus which, like the JC virus, can transform infected cells in culture; up to 80% of the general population (US) have been exposed to it.

Clinical findings
Primary BKV infection is usually subclinical, most common in early childhood, persists in renal epithelium and may become reactivated, causing severe tubulointerstitial nephritis, and cystitis in BM transplant recipients or in immunocompromised patients—e.g., those with hyper-IgM immunodeficiency syndrome; BKV may cause encephalitis.
 
Diagnosis
Serology—IgM, IgG antibodies; PCR; T2-weighted MRI.

BK virus

Infectious disease A small human polyomavirus which, like the JC virus, can transform infected cells in culture; 1º BKV infection is usually subclinical, is most common in early childhood, persists in renal epithelium and may be reactivated, causing severe tubulointerstitial nephritis, and cystitis in BM transplant recipients, or in the immunocompromised Pts–eg, those with hyper-IgM immunodeficiency syndrome; BKV may cause encephalitis Diagnosis Serology–IgM, IgG antibodies; PCR, T2-weighted MRI. See Polyomavirus. Cf JC virus.
References in periodicals archive ?
Laboratory measurements of viral load Cytomegalovirus, Epstein Barr and BK polyomavirus.
116-118) For this and other not entirely understood reasons, BK polyomavirus infection has trophism for transplanted kidneys, and polyomavirus nephropathy has been called the most important infections complication affecting kidney transplant recipients.
Infection with BK polyomavirus (BKPyV) or JC polyomavirus causes substantial illness and death in immunocompromised populations, including transplant recipients and HIV patients (1).
Prospective monitoring of BK polyomavirus infection early post-transplantation in nonrenal solid organ transplant recipients.
BK polyomavirus infection in the renal transplant recipient.
BOSTON -- JC virus, a human polyomavirus known to promote neurologic disease, may lurk in a quarter of all kidney transplant patients suspected of harboring a BK polyomavirus infection, said Pradip Manna, Ph.
Pathologic examination of a bronchoalveolar lavage (BAL) sample showed scattered cells, primarily columnar bronchial cells, with cytomorphologic changes reminiscent of BK polyomavirus (BKPyV) infected decoy cells.
Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients.
Adjuvant Low-dose Cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients.
BK polyomavirus (BKPyV) has been associated with nephropathy in renal transplant recipients and JC polyomavirus (JCPyV) with progressive multifocal leukoencephalopathy in immunocompromised persons (2,3).
Polyomavirus-associated nephropathy (PVAN) is a tubular interstitial inflammatory disease caused by lytic infection of epithelial tubular cells by human BK polyomavirus (BKV) in patients who have undergone kidney transplantation.