Pathologic examination of a bronchoalveolar lavage (BAL) sample showed scattered cells, primarily columnar bronchial cells, with cytomorphologic changes reminiscent of BK polyomavirus
(BKPyV) infected decoy cells.
To date, CMX001 has been used to treat patients with dsDNA viral infections caused by cytomegalovirus, vaccinia virus, herpesviruses (including herpes simplex virus, Epstein-Barr virus and HHV-6,) human papillomaviruses, JC and BK polyomavirus
, and adenovirus.
Correlates of quantitative measurement of BK polyomavirus
(BKV) DNA with clinical course of BKV infection in renal transplant patients.
The viruses most frequently implicated in HC are BK polyomavirus
and adenovirus type 11 [16-18].
BOSTON -- JC virus, a human polyomavirus known to promote neurologic disease, may lurk in a quarter of all kidney transplant patients suspected of harboring a BK polyomavirus
infection, said Pradip Manna, Ph.
(BKPyV) has been associated with nephropathy in renal transplant recipients and JC polyomavirus (JCPyV) with progressive multifocal leukoencephalopathy in immunocompromised persons (2,3).
Polyomavirus-associated nephropathy (PVAN) is a tubular interstitial inflammatory disease caused by lytic infection of epithelial tubular cells by human BK polyomavirus
(BKV) in patients who have undergone kidney transplantation.
(BKPyV) and JC polyomavirus (JCPyV), discovered in 1971 (1,2), are well-known examples of human polyomaviruses (HPyVs) that cause severe disease in immunocompromised patients.
Serologic studies have shown that most adults have been exposed to HPyVs, and cross-reactivity studies have shown antigenic similarities between simian virus 40 and BK polyomavirus
and, to a lesser extent, between simian virus 40 and JC polyomavirus (3-5).
Currently, viruses in this family that infect humans are the opportunistic JC polyomavirus (JCPyV) associated with progressive multifocal leukoencephalopathy in immunocompromised person; BK polyomavirus
(BKPyV) associated with interstitial nephritis and hemorrhagic cystitis; KI polyomavirus (KIPyV) identified in respiratory secretions of patients with respiratory symptoms at the Karolinska Institute (Stockholm, Sweden); WU polyomavirus (WUPyV), isolated from patients with similar symptoms at Washington University (St.