BIRC5


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BIRC5

A gene on chromosome 17q25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. Gene expression is high during foetal development and in most tumours, yet low in adult tissues.

Function
BRIC5 is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation, and is required for chromatin-induced microtubule stabilisation and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. BRIC5 may play a role in neoplasia, counteract default induction of apoptosis in G2/M phase and inhibit caspase-3 and caspase-7.
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a) Common Sequence ID Official gene gene name symbol BAG1 NM_004323 BAG1 Bcl2 NM_000633 BCL2 CCNB1 NM_031966 CCNB1 CD68 NM_001251 CD68 CEGP1 NM_020974 SCUBE2 CTSL2 NM_001333 CTSL2 EstR1 NM_000125 ESR1 GRB7 NM_005310 GRB7 GSTM1 NM_000561 GSTM1 HER2 NM_004448 ERBB2 Ki-67 NM_002417 MKI67 MYBL2 NM_002466 MYBL2 PR NM_000926 PGR STK15 NM_003600 AURKA STMY3 NM_005940 MMP11 SURV NM_001168 BIRC5 -Actin NM_001101 ACTB GAPDH NM_002046 GAPDH GUS NM_000181 GUSB RPLPO NM_001002 RPLP0 TFRC NM_003234 TFRC (a) Genes annotated with NCBI LocusLink sequence identification numbers and official gene symbols of the HUGO Gene Nomenclature Committee (http://www.
Patients whose tumors had gains containing the BIRC5 gene and the DNA damage-binding protein (DDB1) gene (11q12.
Immunohistochemical labeling of several genes including CDKN1A, (12) PSCA, (7,13) MMP7, (14) MUC4, (15,16) CLDN18, (17) ANXA2, (18) BIRC5, (19,20) MUC5, (7) and S100P (21) in multiple PanIN lesions has shown a progressive increase in their expression from low- to high-grade PanINs and leading into invasive cancer.