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BIRC5A gene on chromosome 17q25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. Gene expression is high during foetal development and in most tumours, yet low in adult tissues.
BRIC5 is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation, and is required for chromatin-induced microtubule stabilisation and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. BRIC5 may play a role in neoplasia, counteract default induction of apoptosis in G2/M phase and inhibit caspase-3 and caspase-7.