BIGPRO


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BIGPRO

Biguanides for the Prevention of the Risk of Obesity study. A trial that assessed the use of metformin for primary prevention of insulin resistance syndrome in middle-aged patients with upper-body obesity, which may be linked to ischaemic heart disease and type-2 diabetes.
 
Results
Metformin induced significant weight loss, better fasting glucose control, lower total and LDL C, and a greater reduction of fasting plasma insulin, but had no effect on blood pressure, triglycerides and HDL-cholesterol.
 
Conclusion
Metformin is effective for diabetes, not for heart disease.

Logistics
Randomised, double-blind; 324 patients with upper-body obesity.
References in periodicals archive ?
In addition to real-time event coverage, BigPros will offer databases of sports statistics, media syndication, e-commerce and custom solutions beginning in January 2000.
BigPros is a leading online sports new media company that focuses on building websites and communities for professional athletes.