Best (b st), Charles Herbert 1899-1978. American-born Canadian physiologist noted for the discovery and successful clinical application of insulin. |
BEST
Alternative medicine BioEnergetic Synchronization Technique
Cardiology
(1) Balloon Equivalent to StenT Study
A trial comparing late angiography results of IVUS-guided aggressive PTCA to stenting
Primary endpoints MACE at 1 year
Conclusion IVUS-guided angioplasty with provisional stenting has similar clinical event rates as systematic stenting
(2) Beta-blocker Evaluation of Survival Trial, Bucindolol Evaluation of Survival Trial. A trial assessing the impact on mortality in patients with congestive heart failure of adding a beta blocker—bucindolol-Bextra™—to standard therapy
Logistics Randomised, double-blind, placebo-controlled, stratified; 2,708 patients—1,354 bucindolol, 1,354 placebo—with compensated CHF, NYHA class III/IV, due to dilated cardiomyopathy or coronary disease, LVEF 0.35
Conclusion Mortality 30% with bucindolol, 33% with placebo—p = 0.13
3) Bolus dose-Escalation Study of Tissue-type plasminogen activator A trial that assessed the efficacy of a single bolus of different doseage of tPA in inducing rapid coronary recanalization in patients with AMI
Conclusion A single IV bolus of 0.6 MU/kg of t-PA safely induced rapid coronary patency in patients with acute MI
Neurology A T1-weighted inversion recovery sequence, a variant of the echo-planar technique of MRI, developed by P. Mansfield of Nottingham, UK, used for ultra-high-speed brain imaging
(4) Neurology BEta-blocker Stroke Trial, Low dose beta blockade in acute stroke. A trial that investigated whether the apparent protective effect of propranolol on brain function in patients with subarachnoid haemorrhage applied also to patients with stroke
Results patients who first took beta blockers at stroke onset did worse; those who were already taking beta blockers at the time of the stroke did better
Cardiology
(1) Balloon Equivalent to StenT Study
A trial comparing late angiography results of IVUS-guided aggressive PTCA to stenting
Primary endpoints MACE at 1 year
Conclusion IVUS-guided angioplasty with provisional stenting has similar clinical event rates as systematic stenting
(2) Beta-blocker Evaluation of Survival Trial, Bucindolol Evaluation of Survival Trial. A trial assessing the impact on mortality in patients with congestive heart failure of adding a beta blocker—bucindolol-Bextra™—to standard therapy
Logistics Randomised, double-blind, placebo-controlled, stratified; 2,708 patients—1,354 bucindolol, 1,354 placebo—with compensated CHF, NYHA class III/IV, due to dilated cardiomyopathy or coronary disease, LVEF 0.35
Conclusion Mortality 30% with bucindolol, 33% with placebo—p = 0.13
3) Bolus dose-Escalation Study of Tissue-type plasminogen activator A trial that assessed the efficacy of a single bolus of different doseage of tPA in inducing rapid coronary recanalization in patients with AMI
Conclusion A single IV bolus of 0.6 MU/kg of t-PA safely induced rapid coronary patency in patients with acute MI
Neurology A T1-weighted inversion recovery sequence, a variant of the echo-planar technique of MRI, developed by P. Mansfield of Nottingham, UK, used for ultra-high-speed brain imaging
(4) Neurology BEta-blocker Stroke Trial, Low dose beta blockade in acute stroke. A trial that investigated whether the apparent protective effect of propranolol on brain function in patients with subarachnoid haemorrhage applied also to patients with stroke
Results patients who first took beta blockers at stroke onset did worse; those who were already taking beta blockers at the time of the stroke did better
BEST
Cardiology A clinical trial–Beta-blocker Evaluation of Survival Trial–on the effect of adding bucindolol-Bextra™ to standard therapy on mortality in Pts with CHF; BEST was conducted by the National
Heart, Lung, and Blood Institute/NIH and the VA
Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.
| ?Page tools | ||
|---|---|---|
|