BDNF


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BDNF

A gene on chromosome 11p13 that encodes brain-derived neurotrophic factor, a nerve growth factor that promotes the survival, migration and differentiation of neuronal precursors in the peripheral and central nervous system, and supports survival of primary sensory neurones originating from the neural crest and ectodermal placodes.
References in periodicals archive ?
TrkB Low levels of this protein, which works with BDNF in the brain, have been linked to suicide.
The induction of neurotrophic factors may therefore partially underlie the antidepressant effects of ketamine, given that major depressive disorder is associated with low levels of BDNF and that chronic treatment with antidepressants elevates BDNF levels," he said.
In addition, BDNF and TrkB involves both autocrine and paracrine signaling within bovine oocytecumulus Cell Complex (COCs) (Martins et al.
Direct electrical stimulation to both motor [129-131] and sensory [132] peripheral neuron cell bodies increases BDNF and TrkB expression in those cells and leads to axonal regeneration.
for IL-1(3, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IFN-[gamma], TNF-[alpha], GM-CSF, and MCP-1 (35,45,49-54); RANTES (47,51); TGF-[beta] (52,55); MIP-1[alpha] and MIP-1(3 (47); MMP-9 (56); sTNF RI and sIL-bra (57); MIF (58); NT-3 and NT-4 (59); and BDNF (60, 61).
Staecker et al reported (1) that direct infusion of either neurotrophin-3 or BDNF into the scala tympani of a guinea pig cochlea after a loss of auditory hair cells compensates for the loss of trophic support (i.
Brain-specific phosphorylation of MeCP2 regulates activity-dependent BDNF transcription, dendritic growth, and spine maturation.
According to a recent study, COPAXONE(R) stimulates T-cells to produce the neuroprotection factor BDNF (brain-derived neurotrophic factor) in tissue culture using T-cells from a COPAXONE(R) patient.
Animal studies showed a gene called BDNF is critical to brain mechanisms associated with learning.
Xu is also hopeful about the potential of BDNF as a drug target.