ABCG2

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ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
References in periodicals archive ?
The adoption of the inflation targeting system occurred one year before, in 2002, while the transition (see BCRP, 2003; Armas and Grippa 2005) from control of a monetary aggregate, which was applied during the 1990s, toward control of a short term interest rate started in mid-2001.
Currently, ATPase assays are available for a broad range of human drug transporters including P-gp, BCRP and MRPs.
However, an observable synergistic effect could depend on P-gp or BCRP expression in HER2-negative tumours.
The BCRP in a presentation in June 2006 provided statistics indicating favorable employment growth.
Community safety Police Inspector Will Rees said the re-launch of the BCRP - it was formerly known as the Retail Crime Operation - was a clear example of the strong partnership that existed between the businesses and the police.
Breast cancer cells transduced with control vector (MDA-MB231-pcDNA3) or with a cDNA for the breast cancer resistance protein BCRP (MDA-MB-231BCRP clone 23), human wild-type HCT116 [(p53.
In the present study, we investigated whether P-glycoprotein, BCRP, TP53 and the oncogenic epidermal growth factor receptor (EGFR) as classical mechanisms of drug resistance play a role in the cellular response to honokiol.
The seven identified transporters are: the efflux transporters P-glycoprotein (P-gp, MDR1, ABCB1) and BCRP (ABCG2); organic cation transporter OCT2 (SLC22A2); organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8); and organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3).
The results above indicated that the intestinal absorption of phenylethanoid glycosides such as forsythoside A, isoforsythoside and forsythoside B were influenced by efflux transporters such as P-gp, MRP2, not BCRP.
It is therefore satisfying that neither P-glycoprotein, BCRP, nor knocked-out p53 conferred resistance to compound 1, indicating that this phytochemical might be suited for the development of a novel antineoplasic drug.
BCRP is a protein pump known to pump drugs, including anticancer drugs, from cancer cells that can lead to drug resistance; and also to pump drugs back into gastrointestinal tract, which prevent some useful drugs to be delivered to their target.
2014) also proved that the gene TAGLN2 (encoding transgelin 2) could regulate the activity of the promoters of MDR1, MRP1, and BCRP and for this reason transgelin 2 could modulate the expressions of classic resistance protein P-gp, MRP1, and BCRP.