BCR

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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
The isolates were subjected to recA PCR amplification using the oligonucleotide primers BCR1 and BCR216.
The laboratories also received calibrators prepared by cloning PCR products of samples from positive patients (B3A2 isoform for BCR-ABL, and BCR1 or BCR3 isoforms for PML-RARa) into CR[R] II-TOPO[R] vector (TOPO[TM] Cloning[R] Kit).
The full-length recA gene was amplified from these isolates by using primers BCR1 and BCR2 (17).