BCR


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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
Similar to early BCR, all clinical variables evaluated except race/ethnicity were associated with early BCR in univariable analysis.
Variance of patients in terms of etiological factor, neurological level, lesion severity, presence of TPS and BCR, frequency of storage, and emptying dysfunction and type of detrusor n = 59 Etiological factor (Traumatic/ 54/5 Non-traumatic) Neurological level (Cervical/Thoracic/ 13/30/16 Lumbosacral) Lesion severity (Complete/Incomplete) 34/25 TPS (Present/Absent) 20/39 BCR (Present/Absent) 50/9 Frequency of storage dysfunction 35 Frequency of emptying dysfunction 56 Type of detrusor (Overactive/ 48/11 Acontractile-underactive) TPS: Toe position sense; BCR: bulbocavernosus reflex Table 2.
It is the sale of the Bell Centre and the winding up of BCR as a charity, meeting the requirements of the Charity Commission, and the payment of all debts which is the priority for the trustees.
La posicion de los puntos de ruptura en los genes BCR y ABL se asocian con caracteristicas clinicas-morfologicas de la LMC y LLA Ph+, determinadas por el efecto de la composicion y estructura de las proteinas de fusion producidas por los diferentes rearreglos genomicos, producto de la t(9;22)(q34;q11) (Pane et al.
The 50-year-old Burbank resident and fitness trainer began to volunteer at BCR nine years ago, about the time he was changing careers and wondering what his legacy would be.
Una de las tecnicas mas usadas es la PCR con transcripcion reversa (RT-PCR), mediante la cual a partir de secuencias del ARN mensajero es posible detectar transcriptos de fusion del gen BCR-ABL e identificar diferentes reordenamientos segun el punto de ruptura dentro del gen BCR, con mayor sensibilidad y especificidad que con el estudio citogenetico (Cross, 1996 y Artigas et al.
Other BCR signaling inhibitors provide external validation to this approach
The loan is to be provided in two equal tranches and will allow BCR to finance SMEs through investments loans, revolving credit facilities, loans for working capital, financing for leasing or other instruments.
The rest of the BCR stock is owned by a number of smaller shareholders.
Credit Suisse has lent EUR75m, BCR has provided EUR100m and CEC has secured a further EUR25m, according to daily Ziarul Financiar.
BCR announced that Justine Shaffner has joined the company in the newly created position of public library market coordinator.
The resulting fusion gene (BCR-ABL) (1, 2), which has breakpoints at BCR exon b2 or exon b3 and at ABL exon a2, produces a p210 chimeric BCR-ABL tyrosine kinase with a deregulated activity that plays a key role in CML development (3).