BCR


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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
Table 1/Options Analysis Example (Scenario 1) Discounted Discounted Costs NPV BCR Benefits 1A 200,000 120,000 80,000 1.
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In a statement, the chairman of BCR Mike Duxbury said: "We are saddened to hear that Rhondda Life has gone into receivership and regret that another initiative to help regenerate the upper Rhondda Fach and bring employment and opportunity to the community seems to have failed.
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Which of the following is MOST suspicious of a BCR diagnosis?
Our objective was to report the time from the first detectable PSA to 4 commonly used definitions of BCR and to identify predictors of time to BCR.
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Molecular experiments indicate that abnormal BCR signaling can contribute to the genesis of NHL, and support the use of BCR signaling inhibitors as a therapeutic approach.
4, 2014 /PRNewswire/ -- Deana Starkey Martin has joined BCR REALTORS in Bryan/College Station, Texas as their new Sales Manager, Coach and Recruiter.
The European Investment Bank (EIB) is lending EUR 30 million to BCR Leasing to support the undertakings of small and medium-sized enterprises (SMEs), midcap companies and public entities in the sectors of industry, services and infrastructure in Romania.
Romania's BCR Banca pentru Locuinte (BpL), the supplier of Bauspar products (saving-lending for the housing sector), said on Wednesday that 19 percent of its clients aged 18 to 34 are looking to take out an "immediate" loan, according to an IRSOP study commissioned by the company.