BCNU


Also found in: Dictionary, Acronyms, Idioms, Encyclopedia, Wikipedia.

carmustine

 [kahr-mus´tēn]
a cytotoxic alkylating agent of the nitrosourea group, used as an antineoplastic agent, primarily against brain tumors, multiple myeloma, colorectal carcinoma, Hodgkin's disease, and non-Hodgkin's lymphomas. Called also BCNU.

car·mus·tine

(kar-mŭs'tēn),
An antineoplastic agent.
Synonym(s): BCNU

BCNU

carmustine.

BCNU

BCNU

A chemotherapeutic related to lomustine (CCNU) and semustine, which partially overlaps the activity/toxicity of alkylating agents.
 
Indications
Hodgkin lymphoma, non-Hodgkin lymphoma, melanoma, myeloma, brain tumours, gastrointestinal carcinomas; BCNU crosses the blood-brain barrier and may be used for meningeal leukaemia and brain tumours.
 
Side effects
Nausea, vomiting, decreased platelets, reduced WBCs, secondary leukaemia, pulmonary fibrosis, renal failure.

BCNU

Bis-chlorethylnitrosourea, carmustine A chemotherapeutic related to lomustine–CCNU and semustine, which partially overlaps the activity/toxicity of alkylating agents Indications Hodgkin's disease, possibly NHL, melanoma, myeloma, brain tumors, GI carcinomas; BCNU crosses the blood-brain barrier and may be used for meningeal leukemia and brain tumors Side effects N&V, ↓ platelets, ↓ WBCs, 2º leukemia, pulmonary fibrosis, renal failure

BCNU

References in periodicals archive ?
The BCNU represents registered and registered psychiatric nurses and was formed in 1981 after separating from the then Registered Nurses' Association of British Columbia.
The effect was found to be more significant than that of BCNU (which is clinically used for this indication) or of Gleevec(R), another approved anti-cancer drug.
PLA nanoparticles for controlled delivery of BCNU to brain tumors 287
As a Gliadel Wafer dissolves, BCNU is delivered directly to the site once occupied by the tumor, providing site-specific chemotherapy to target any remaining tumor cells.
b) after glioma recurrence following (a), administering a regimen of chemotherapy to said mammal, wherein said regimen of chemotherapy includes the administration of at least one chemotherapeutic agent selected from the group consisting of temozolomide, procarbazine, vincristine, BCNU, CCNU, thalidomide, irinotecan, isotretinoin, imatinib, etoposide, and combinations thereof.
A GLIADEL(R) Wafer delivers BCNU (or carmustine), a commonly used chemotherapeutic anti-tumor agent for GBM, directly to the brain tumor resection cavity.
Gliadel (polifeprosan 20 with carmustine implant) Wafer is a biodegradable wafer containing the chemotherapy agent carmustine, or BCNU, approved for the treatment of high-grade malignant gliomas as an adjunct to surgery and radiation.
Results from the study demonstrated that treatment with ZADAXIN plus BCNU led to significantly lower tumor burdens and increased cure rates as compared to treatment with BCNU alone.