BCL9

BCL9

A gene on chromosome 1q21 that encodes a phosphoprotein involved in signal transduction through the Wnt pathway, and which promotes beta-catenin's transcriptional activity.
References in periodicals archive ?
Scientists created the new molecule after studying another naturally occurring molecule called BCL9, which transmits signals sent by Wnt in cancer cells but not in healthy cells.
This work builds on ours and [that of] other groups, and shows that it's possible to block the cancer-promoting interaction between BCL9 and beta-catenin, two key proteins in the Wnt signalling pathway," said Dr Mariann Bienz, a scientist from the MRC Laboratory of Molecular Biology in Cambridge, England.