BCL10


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BCL10

A gene on chromosome 1p22 that encodes a protein which contains a caspase recruitment domain (CARD); it induces apoptosis, activates NF-kappaB and interacts with other CARD domain proteins (e.g., CARD9, 10, 11 and 14), which are thought to act as upstream regulators in NF-kappaB signalling.

Molecular pathology
BCL10 protein product forms a complex with MALT1, a protein encoded by a gene that is translocated in MALT lymphoma and together activate NF-kappaB; deregulation of either BCL10 or MALT1 may lead to MALToma.
References in periodicals archive ?
Acinar differentiation, which is the most common, results in trypsin, chymotrypsin, lipase, and BCL10 positivity, making distinction from ACC challenging unless one identifies pathognomonic squamoid morules, and even primitive (blastemal) elements.
Summary of Useful Markers for Acinar Cell Carcinoma (ACC), Pancreatic Neuroendocrine Tumor (P-NET), Solid Pseudopapillary Tumor (SPT), and Pancreatoblastoma (PB) Antibodies ACC P-NET SPT PB [beta]-catenin M or rarely N + C M N + C N + C or M+ E-cadherin + + - - or + Chromogranin - + - - or + CD10 - + + - or + Trypsin + - - + Glypican 3 + or - - - ND BCL10 + - - ND Abbreviations: +, usually more than 75% of cases are positive; /, less than 5% of cases are positive;+ or /, usually more than 50% of cases are positive; /or +, less than 50% of cases are positive; BCL10, B cell CLL/lymphoma 10;C, cytoplasmic staining;CD10, cluster of differentiation 10; CLL, chronic lymphocytic leukemia; M, membranous staining;N, nuclear staining;ND, no data.
Nuclear expression of BCL10 or nuclear factor kappaB helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphoma with and without t(11;18)(q21;q21).