BCL6

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BCL6

A gene on chromosome 3q27 that encodes a zinc finger transcription factor that acts as a sequence-specific repressor of transcription. BCL6 modulates the transcription of START-dependent IL-4 responses of B cells, and interacts with various POZ-containing transcription co-repressors.

Molecular pathology
BCL6 is often translocated (e.g., t(3;14)(q27;q32); t(3;22)(q27;q11)) and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in DLCL pathogenesis.
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For oral administration, BCL-1, 400 mg/kg; BCL-2, 800 mg/kg; BCL-3, 1600 mg/kg; BCL-4, 3200 mg/kg; BCL-5, 6400 mg/kg.