BCHE


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BCHE

A gene on chromosome 3q26.1-2 that encodes butyrylcholinesterase, which has a broad substrate spectrum. It contributes to inactivation of the neurotransmitter acetylcholine and can degrade neurotoxic organophosphate esters.
 
Molecular pathology
Mutant alleles at BCHE are responsible for suxamethonium sensitivity.
References in periodicals archive ?
The hydrogen bonds formed with the amino acid residues at the catalytic site could be responsible for the potency of angustidine (2) as a BChE inhibitor.
Three quantitative BChE variants have been described: James (J), Kalow (K), and Hammersmith (H).
3 [micro]M) while 1,5-dihydroxyxanthone was the most active BChE inhibitor ([IC.
aurantifolia oil against AChE and BChE were 140 [+ or -] 35 [micro]g/m1 and 42 [+ or -] 5 p.
There have been few attempts to map the entire AChE or BChE primary sequence using MS.
A mutation detection approach can be used for investigation and characterization of BCHE variants because the phenotype is defined, the gene is relatively small [73 kb; four exons interrupted by three introns with exon 1 not translated; coding region 1722 nucleotides], and most abnormalities described are point mutations.
Inclusion of additional polymorphisms in FMO3 and BCHE, especially those in the promoter region, would be worthwhile.
4) For >30 years, serum BCHE activity, dibucaine number (DN), and fluoride number (FN) have provided sufficient information to identify most of the known BCHE phenotypes associated with succinylcholine sensitivity [1].
Naro holds a BChE in Chemical Engineering from the University of Delaware and an MBA in finance from The Wharton School of Business at the University of Pennsylvania.