BAP1

BAP1

A gene on chromosome 3p21.31-p21.2 that encodes a tumour-suppressing enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. BAP1 forms the catalytic component of the PR-DUB complex, which specifically mediates deubiquitination of histone H2A monoubiquitinated at “Lys-119”. BAP1 is also a less preferred gene symbol for what is now designated as MAGI1, see there.
References in periodicals archive ?
The current NeoGenomics offering includes individual gene testing of BRCA1, BRCA2, MLH1, MSH2, EPCAM, MSH6, PMS2 genes as well as a comprehensive 73 gene panel that includes the following genes: AKT1, APC, ATM, ATR, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, DKN2A, CEBPA, CHEK1, CHEK2, CTNNA1, EPCAM, ETV6, FAM175A, GALNT12, GATA2, GEN1, GREM1, HOXB13, KLLN, MEN1, MLH1, MRE11A, MSH2, MSH6, MUTYH, MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, NBN, NTRK1, PALB2, PIK3CA, PMS2, POLD1, POLE, PPM1D, PRSS1, PTEN, RAD50, RAD51, RAD51C, RAD51D, RET, RUNX1, SDHB, SDHC, SDHD, SMAD4, STK11, TERC, TERT, TP53, TP53BP1, VHL, WT1, XRCC2.
DNA methylation profiles, microRNA dysregulation, and BAP1 mutations are being studied, which are likely to yield important results in understanding pathogenesis and developing targeted therapy for MM, but are currently not used for diagnosis.
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.
BAP2: A manufacturing line similar to BAP1, but with realistic real-world processing times: the times are offset by a minimum (a task cannot be executed in less time), and the distributions are truncated (a task has a finite duration).
The approximation set to the Pareto front (PF) for BAP1 is shown in Fig.
Processing Rejection times rate BAP3 Machine BAP1 BAP2, 3 Quality Final 1 1.
This analysis identified eight new breast cancer risk genes (ATR, BAP1, CHEK1, GEN1, KANK4, OBSL1, RAD51B, and TP53BP1), some of which are now included on clinically available cancer risk panels (C.
This discovery is a first step in understanding the role of the BAP1 gene and its potential utility when screening for mutations in those at high risk," said Michele Carbone, M.
The study also found evidence that some people with BAP1 gene mutations also developed breast, ovarian, pancreatic or renal cancers, suggesting that the gene mutation may be involved in multiple cancer types.
The team found mutations in a gene called BAP1 in 84 percent of the metastatic eye tumors they studied.
Very few such genes have been identified, but this finding strongly implicates BAP1 as a new member of that small group.
More recently, he and his research team discovered the BAP1 tumor suppressor gene and described its role in regulating BRCA1 function and in the development of breast and lung cancers.