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A gene on chromosome 22q12.2 that encodes a putative regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a key role in tumour suppression by restricting proliferation and promoting apoptosis. NF2 may act as a membrane-stabilising protein, and it may inhibit PI3 kinase by binding to AGAP2 and downregulating its stimulating activity. NF2 suppresses cell proliferation and tumourigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Molecular pathology
NF2 defects cause:
• Neurofibromatosis 2;
• Schwannomatosis; and
• Mesothelioma (some cases).


Bilateral acoustic neurofibromatosis. See Neurofibromatosis, type 2.
References in periodicals archive ?
BANF acting chairman Zhor Malik said Mr Rice would be granted an appeal.
Both B: Cen and Banf have encouraged members to debate the issue of whether they should be consulted over how the city is run.
Fitch will not perform ongoing surveillance of BANF.
Chairman of BANF Victor Cox, who also chairs the Falcon Lodge Neighbourhood Forum, said members were "very concerned"
Members of the Birmingham Association of Neighbourhood Forums, or BANF, are backing calls for a referendum on how the city's mayor is elected.
And at the BANF annual meeting there were also demands for neighbourhood councils to run public and community services at a grass roots level.
BANF chairman Victor Cox, of the Falcon Lodge Neighbourhood Forum, pledged to campaign to strengthen the local residents' groups.
Victor Cox, aged 54, chairman of BANF and Falcon Lodge Neighbourhood Forum, said: "I am for the referendum because people need to be given the choice and this meeting proved how interested people are in the issue.
00 The Canadian Rockies Flying from London Gatwick Departs April, May, June, September, October 2015, April, May & June 2016 This escorted tour of Western Canada includes a journey through the Rockies from Banff, Banf visits to Jasper and Whistler, and sparkling Vancouver.