GRB7

(redirected from B47)

GRB7

A gene on chromosome 17q12 that encodes an adapter protein which interacts with the cytoplasmic domain of numerous downstream protein kinases (e.g., STAT3, AKT1, MAPK1 and/or MAPK3), activating them. GRB7 promotes activation of HRAS; it plays a role in signal transduction in response to EGF and in regulating cell proliferation and cell migration. It also plays a role in the assembly and stability of RNA stress granules, binding target mRNA molecules and repressing their translation when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery from cellular stress.
References in periodicals archive ?
Adjustments in lines A5, A13, B12, B47, and B82 reflect CENSUS's
In the course of this project the junction B47 / K17 needs to be expanded and existing elements are upgraded.
Four-cylinder units will also be offered and will include the new BMW B47 diesel engine, available in the 118d, 120d and 125d.
People in London can see the product at "The Back Pain Show" on July 4-6, 2014 in Strand B47, Olympia Grad Hall, W14-8, London.
After the Giant's Causeway, the B47 takes you through some of Ireland's most spectacular scenery.
This deletion pattern is often seen as part of an extended MHC haplotype that includes the HLA markers A3, B47, and DR7.
The Campaign for Nuclear Disarmament yesterday released a secret government report on the accident in 1958 when fire destroyed a B47.
B47, covering Hollywood and Wythall, B48, Alvechurch, B50, Alcester, and B60, Bromsgrove, all have an average of six rooms.
B47 6JR VICKERS Margery (nee Wright) Wife of Ron (deceased).