ARID1A

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ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
With Vicat B120 softening temperatures as high as 190C and glass transition temperatures (Tg) of up to 195C, LEXAN CXT resins can provide converters with the potential to injection mold parts that can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
With Vicat B120 softening temperatures as high as 190AaAaAeAaC and glass transition temperatures (T of up to 195C, Lexan CXT resins can provide converters with the potential to injection mold parts that can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
With Vicat B120 softening temperatures as high as 190[degrees]C and glass transition temperatures (Tg) of up to 195C, Lexan CXT resins can provide converters with the potential to injection mold parts that can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
CIRCUS ACTS THERE will be stories and faces from the circus during an event which will be using non-toxic face paints at Small Heath Library, Muntz Street B120 9RX from 10.
45 MPa [degrees]C IS075/Bf 136 Vicat B120 [degrees]C IS0306 142 Rheological MVR ** cc/10min IS01133 12 Impact Notched Izod kJ/[m.
The movie features the Cadillac Cien concept car and Confederate's Wraith B120.
He has served in a wide variety of Naval Reserve billets including six command tours as Commanding Officer of Advanced Supply Base 420, Naval Air Pacific Supply 187, Navy Material Transportation Detachment 520, Defense Contract Management District B 1020, Defense Distribution Depot Oakland Headquarters B320, and Defense Distribution Region West Headquarters B120.
B120 was developed by pedigree selection from BSCB1(R)-C12; pedigree of B120 is BSCB1(R)C12-6826-1-1-1-1-1-1-B.
Significant contribution to the achievement of one year without a lost-time accident on the Cox B120 extension project at the Novartis Pharmaceutical manufacturing facility in Grimsby.
Menopausal women are also actively seeking other nutrients (omega-3 oils and B vitamins, including folic acid, B6 and B120 while begging for their inclusion in foods.
Her recent Reserve assignments include Commanding Officer, AIRPAC Supply 0189 and Executive Officer, NR Defense Distribution Center Detachment B120.