It is generally agreed that the normal T- to B-lymphocyte
ratio in the peripheral blood is about 4:1, and the CD4 to CD8 ratio is about 2:1.
Instead, experiments which eliminated the macrophages from the mouse models showed that it was actually the resident DCs in the lymph nodes that were bringing the flu virus to the B-lymphocytes
, thus inducing the B-lymphocytes
to launch an antibody attack.
Ordinarily, the proliferating B-lymphocytes
form a chorus line of cells that rapidly divide to HIV's tune, Herndier explains.
The standard of care for the treatment of most cases of DLBCL is the R-CHOP regimen--multi-agent chemotherapy plus a therapeutic antibody directed against CD20, a marker of B-lymphocytes
Rituximab is a monoclonal antibody against CD20 antigen expressed on B-lymphocytes
Counts of macrophages, neutrophils, B-lymphocytes
and T-lymphocytes were expressed as the number of white cells per number of muscle fibers and the number of white cells per cross-sectional area.
tinctoria on IgM-production might be due to a direct influence on B-lymphocytes
or indirectly caused by activation of macrophages followed by the release of IL6.
It is a laboratory manufactured monoclonal antibody that specifically targets the CD52 antigen present on 95 per cent of normal and malignant B-lymphocytes
,' he said.
In view of its expected increased generation at sites of inflammation, because of the presence of a large number of T- and B-lymphocytes
, it is much more likely to act similarly to a paracrine or autocrine agent.
T-lymphocytes reject foreign bodies and stimulate B-lymphocytes
to produce antibodies.
Multiple myeloma is a cancer of the blood characterized by the spread of cancerous B-Lymphocytes
that lead to damage to normal cells and bone.
The candidates are both immunotoxins comprising an antibody fragment that targets the CD22 receptor on B-lymphocytes
fused to a toxin molecule.